ReviewRoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin2026
MRI after Interventional Therapy of Hepatocellular Carcinoma: Typical Changes over Time.
Review in RoFo : Fortschritte auf dem Gebiete der Rontgenstrahlen und der Nuklearmedizin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Interventional therapies for hepatocellular carcinoma (HCC) include various methods such as transarterial chemoembolization (TACE), radiofrequency and microwave ablation (RFA, MWA), selective internal radiotherapy (SIRT), and stereotactic body radiation therapy (SBRT). Imaging follow-up using magnetic resonance imaging (MRI) is essential for the early detection of recurrence, but requires profound knowledge of therapy-related imaging changes. Materials & Methods: A structured PubMed literature search covering the period from 2000 to 2025 was conducted using the keywords "hepatocellular carcinoma," "magnetic resonance imaging," "thermal ablation," "transarterial chemoembolization," "transarterial radioembolization," "stereotactic body radiotherapy," and "treatment response." In addition, the study incorporated current national and international guidelines, as well as institutional clinical experience. Results: Post-interventional imaging changes on MRI vary depending on the therapeutic approach applied. Typical morphological changes are observed immediately after thermoablation and TACE, whereas therapeutic effects of SIRT and SBRT become clearly evident only after weeks to months. Profound knowledge of standardized evaluation systems such as mRECIST, EASL, and LI-RADS-TR is crucial to ensure a precise and structured assessment of therapeutic response. Conclusion: Knowledge of specific MRI findings and standardized assessment systems is essential for structured follow-up of hepatocellular carcinoma after interventional therapy. Limitations arise from the heterogeneity of imaging findings, variable temporal patterns, and potential influences of combination therapies. Systemic therapies were not considered, restricting generalizability. Key Points: · Magnetic resonance imaging is essential for assessing treatment response and for the early detection of recurrence after interventional therapy of hepatocellular carcinoma.. · Morphological changes after therapy are procedure-dependent and show marked differences over time: SIRT and SBRT demonstrate delayed changes, whereas TACE and thermal ablation present immediate effects.. · Standardized classification systems (mRECIST, EASL, LI-RADS-TR) provide a structured and reproducible framework for evaluating treatment response.. · Knowledge of characteristic imaging findings and potential pitfalls is crucial to reliably differentiate between residual tumor, recurrence, and therapy-induced changes.. · This review contributes to the current body of knowledge by systematically consolidating available evidence and presenting it in a practice-oriented manner in the context of MRI follow-up imaging.. Citation Format: · Kübler J, Ashkar A, Winkelmann MT et al. MRI after Interventional Therapy of Hepatocellular Carcinoma: Typical Changes over Time. Rofo 2025; DOI 10.1055/a-2724-6488.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.