ArticleCell metabolism2025
Endothelial senescent-cell-specific clearance alleviates metabolic dysfunction in obese mice.
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Article in Cell metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10citing papers in PubMed
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Who cites it
10 citing papers in PubMed.
- Cellular senescence: six decades of discovery and reinvention.The EMBO journal · 2026Review
- Senolytics dasatinib and quercetin in metabolic dysfunction-associated steatohepatitis: a proof-of-principle randomized, controlled trial.Nature metabolism · 2026Article
- Review
- Article
- Article
- The Sphingolipid Balance and Endothelial Dysfunction in Lysosomal Storage Diseases: Shared Mechanisms in Gaucher, Niemann-Pick and Fabry Disease.International journal of molecular sciences · 2026Review
- Distinct senescent β-cell senotypes differentially drive islet aging and dysfunction.bioRxiv : the preprint server for biology · 2026Article
- Review
- p21Nature aging · 2026Article
- Osteoprotegerin-Enabled Immune Evasion of Pathological Adipose Stromal Cells Drives Metabolic Dysfunction in Obesity.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
26 authors.
Masayoshi SudaCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA; Department of Cardiovascular Biology and Medicine, Juntendo University Graduate School of Medicine, 3-1-3 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. Electronic address: masayoshi.suda@cshs.org.
Selim ChaibCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Larissa G P Langhi PrataCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Yi ZhuDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Sam and Ann Barshop Institute for Longevity and Aging Studies, Department of Cellular and Integrative Physiology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USA.
Utkarsh TripathiDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Karl H PaulDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Allyson K PalmerDivision of Hospital Internal Medicine, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Tamar PirtskhalavaCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Vagisha KulshreshthaMayo Clinic Graduate School of Biomedical Sciences, Rochester, MN 55905, USA.
Christina L InmanDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Kurt O JohnsonDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Nino GiorgadzeCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA.
Runqing HuangRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.
Carolyn M RoosRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.
Luisa F Leon-SanchezRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.
Jordan D MillerRobert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Department of Cardiovascular Surgery, Mayo Clinic College of Medicine, 200 First St., S.W., Rochester, MN 55905, USA.
Thomas WhiteDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Linshan LauxMasonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.
Laura J NiedernhoferMasonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.
Paul D RobbinsMasonic Institute on the Biology of Aging and Metabolism, Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, E, Nils Hasselmo Hall, 312 Church Street S.E., Minneapolis, MN 55455, USA.
Sara EspinozaCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA.
Nicolas MusiDivision of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
Sundeep KhoslaDepartment of Physiology and Biomedical Engineering, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First St., S.W., Rochester, MN 55905, USA.
Stefan G TulliusDivision of Transplant Surgery, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, 45 Francis St., Boston, MA 02115, USA.
Tamar TchkoniaCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA.
James L KirklandCenter for Advanced Gerotherapeutics, Cedars-Sinai Medical Center, Pacific Design Center, 8687 Melrose Avenue, West Hollywood, CA 90048, USA; Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, 8700 Beverly Boulevard, Los Angeles, CA 90048, USA. Electronic address: james.kirkland@cshs.org.
Funding
Targeting Cellular Senescence to Extend HealthspanP01AG062413 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, Nathan K LeBrasseur · 2019 to 2026
$28.7MMidwest Murine-Tissue Mapping Center (MM-TMC)U54AG079754 · NIA · UNIVERSITY OF MINNESOTA · PI GR Scott Budinger, Sundeep Khosla · 2022 to 2026
$11.5MPROTEOMICSP01AG043376 · NIA · UNIVERSITY OF MINNESOTA · PI ROBBINS, PAUL D. · 2013 to 2019
$11.2MEffect of Aging on Preadipocyte DifferentiationR37AG013925 · NIA · MAYO CLINIC ROCHESTER · PI KIRKLAND, JAMES L. · 2016 to 2025
$6.6MTranslational Geroscience NetworkR33AG061456 · NIA · MAYO CLINIC ROCHESTER · PI JAMES L. KIRKLAND, STEPHEN B. KRITCHEVSKY · 2019 to 2026
$6.2MUsing the senolytic fisetin to suppress mortality in aged mice acutely exposed to murine beta-coronavirusR01AG063543 · NIA · UNIVERSITY OF MINNESOTA · PI NIEDERNHOFER, LAURA JANE · 2019 to 2023
$3.4MDefining the interactions of senescent immune cells and skeletal cellsR01AG076515 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2022 to 2026
$2.4MCharacterization of senescent cell populations in skeletal agingR01AG086085 · NIA · MAYO CLINIC ROCHESTER · PI Sundeep Khosla, David G Monroe · 2024 to 2026
$1.6MInvestigating the Role of Adipose Senescent Cells in Cognitive Function and Alzheimer's Disease ProgressionR01AG087387 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Yi Zhu · 2024 to 2026
$1.5MSenescent Cells Effects in Response to PathogensK01AG090692 · NIA · CEDARS-SINAI MEDICAL CENTER · PI Larissa Gutman Paranhos Langhi Prata · 2025 to 2026
$325kNIA NIH HHS K01 AG090692NIA NIH HHS P01 AG043376NIA NIH HHS P01 AG062413NIA NIH HHS R01 AG063543NIA NIH HHS R01 AG076515NIA NIH HHS R01 AG086085NIA NIH HHS R01 AG087387NIA NIH HHS R33 AG061456NIA NIH HHS R37 AG013925NIA NIH HHS U54 AG079754
Abstract
Accumulation of senescent cells is a key contributor to multiple diseases across the lifespan, including metabolic dysfunction. We previously demonstrated that elimination of senescent cells using senolytic drugs alleviates obesity-induced metabolic dysfunction. However, the contribution of senescent endothelial cells to metabolic disorders remains elusive. Hence, we crossed mice that allow selective elimination of senescent cells (p16
Indexed as
Cellular SenescenceEndothelial CellsObesityAdipose TissueAnimalsCyclin-Dependent Kinase Inhibitor p16FlavonoidsMaleMiceMice, Inbred C57BLMice, ObeseCyclin-Dependent Kinase Inhibitor p16Flavonoidscellular senescencediabetesendothelial cellsfisetinglucose intoleranceobesityp16(Ink4a)SASP factorssenolyticsTNFα
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.