ArticleChemistry & biodiversity2026
Anti-Aging Activity of Rosa roxburghii Nano-Emulsion in Caenorhabditis elegans: Preparation, Characterization, and Evaluation.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Sustainable Ellagitannin-Rich Pomegranate Peel Extracts Activate SKN-1/NRF2-Dependent Antioxidant Responses and Promote Healthy Aging inAntioxidants (Basel, Switzerland) · 2026Article
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Authors and funding
5 authors.
Funding
Abstract
The triterpenoids in Rosa roxburghii fruit (RRF) show various pharmacological activities such as antioxidant, anti-ageing, and anti-atherosclerotic. However, the therapeutic potential of these triterpenoids is limited by poor aqueous solubility, low bioavailability, and rapid systemic clearance, which can hinder their oral effectiveness. The objective of this study was to prepare an RRF nano-emulsion (RRFNE), which is conducive to enhancing the bioactivity of RRF following oral administration. The polydispersity index of RRFNE was 0.18, diameter 43.95 nm, zeta potential 36.37 mV, and triterpenoids loading 25.02 mg/g. Compared to RRF-100, the longest lifespan of RRFNE-100 was extended by 8.58%. The activities of catalase, superoxide dismutase (SOD), and glutathione peroxidase in RRFNE-100 increased by 11.33%, 16.19%, and 5.37% (p < 0.01), respectively, and malondialdehyde levels decreased by 8.98%. Additionally, RRFNE enhances the antioxidant capacity of C. elegans by activating the expression of SIR-2.1, DAF-16, and SOD-3, thus extending the nematodes' lifespan without affecting their reproductive ability.
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