ArticleChemistry & biodiversity2026
Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
2 citing papers in PubMed.
- Assessment of the Acute Toxicity and Anxiolytic-Like Effect of α-Humulene in Adult Zebrafish (Danio rerio).Chemistry & biodiversity · 2026Article
- Serotonergic Neuromodulation of Natural Products Isoreserpine and Isoreserpiline in Adult Zebrafish: An in Silico and In Vivo Investigation.Chemistry & biodiversity · 2026Article
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anxiety is a multidimensional behavioral disorder widely studied in neuroscience due to the involvement of specific neural circuits. Although benzodiazepines are commonly used, their side effects drive the search for new therapeutic alternatives. This study investigated the anxiolytic effects of the indole alkaloids isoreserpine (IRPN) and isoreserpiline (IRPL), extracted from Rauvolfia ligustrina, in adult zebrafish at doses of 4, 12, and 20 mg/kg, along with 3% DMSO and diazepam (4 mg/kg) as controls. Toxicity, locomotor activity, anxiolytic effects, and serotonergic involvement were assessed. Interactions with the 5-HT3AR receptor were analyzed through molecular docking, and pharmacokinetic properties were evaluated using DMPK. The samples showed no toxicity (LD
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