Evidence map›Paper›PMID 41270186›Full record

SynthesisThe Journal of urology2026

Effect of Postdiagnosis Diet and Lifestyle on Clinical Outcomes in Prostate Cancer Survivors: A Systematic Review.

Ryan Allen, Vivian Liu, June M Chan, Rebecca E Graff, Meir J Stampfer, William J Aronson, Stacey A Kenfield

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in The Journal of urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ryan AllenChicago College of Osteopathic Medicine, Midwestern University, Chicago, Illinois.ORCID 0000-0003-1254-0373
Vivian LiuDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.ORCID 0009-0005-9013-4022
June M ChanDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.
Rebecca E GraffDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.ORCID 0000-0003-0316-8303
Meir J StampferDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.ORCID 0000-0001-8865-935X
William J AronsonDepartment of Urology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California.
Stacey A KenfieldDepartment of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California.ORCID 0000-0002-1585-7352

Funding

Role of GPR120 and Macrophages in Dietary Omega-3 Fatty Acid Inhibition of Prostate CancerR01CA231219 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARONSON, WILLIAM J, COHEN, PINCHAS · 2018 to 2022
$2.1M
NCI NIH HHS R01 CA231219
6 · The paper itself

Abstract

purposeTo determine whether postdiagnosis dietary patterns, lifestyle scores, and related indices are associated with prostate cancer (PCa) clinical outcomes, with the goal of informing evidence-based strategies for survivorship and secondary prevention. MATERIALS AND

methodsAdult men (≥18 years) diagnosed with PCa. Clinical trials and cohort studies reporting on PCa progression, recurrence, PCa-specific mortality (PCSM), and PSA kinetics. All-cause mortality (ACM) was considered only when accompanied by PCa-specific endpoints. PubMed, Embase, and the Cochrane Library were searched from January 1, 2005, to May 3, 2025. Eligible studies assessed individual-level postdiagnosis diet or lifestyle exposures using diet or composite indices. Titles and abstracts were screened by 2 independent reviewers, with full texts of eligible studies assessed in duplicate.

resultsA total of 21 studies were included. Although not all studies agree, several studies suggest that eating plant foods, adopting healthful diets and lifestyle patterns (as defined herein), and minimizing consumption of inflammatory foods and those with higher insulinemic potential may potentially lower the risk of PCa progression and PCSM. The data also indicate that following Mediterranean, Healthy Eating Index, and Prudent dietary patterns, healthy behaviors, and World Cancer Research Fund/American Institute of Cancer Research recommendations are associated with lower risk of ACM, while the Western dietary pattern and eating foods with higher insulinemic potential are associated with increased risk of ACM.

conclusionsCurrent evidence suggests that healthy dietary practices combined with healthy lifestyle behaviors (not smoking, regular physical activity, maintaining a healthy weight) may reduce PCa progression and ACM, with some evidence reported for PCSM. Additional robust cohort and interventional studies with longer follow-up and a greater number of PCSM events are needed. Consideration should be given to incorporating principles of healthy diet and lifestyle as part of PCa survivorship care. A summary table with diet and lifestyle recommendations is provided for healthcare providers.

Indexed as

Cancer SurvivorsDietLife StyleProstatic NeoplasmsDiet, HealthyDisease ProgressionHumansMalecancermortalityprogressionprostaterecurrencesurvival

Identifiers

PMID41270186
PMCPMC13095399

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.