Evidence map›Paper›PMID 41270173›Full record

ArticleScience advances2025

Electrochemical C4 alkylation of pyridine derivatives: Enhanced regioselectivity via silane assistance.

Zhihao Yang, Xuan Liu, Yi-Xuan Chen, Yuting Gao, Xun Xiao, Hirofumi Maekawa, Tianyuan Zhang, Xin-Qi Hao, Mao-Ping Song

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Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhihao YangCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.ORCID 0009-0006-4447-4410
Xuan LiuCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.
Yi-Xuan ChenCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.ORCID 0009-0004-6753-7053
Yuting GaoCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.
Xun XiaoCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.
Hirofumi MaekawaDepartment of Materials Science and Bioengineering, Nagaoka University of Technology, 1603-1 Kamitomioka-cho, Nagaoka, Niigata 940-2188, Japan.
Tianyuan ZhangCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.ORCID 0000-0003-0071-5295
Xin-Qi HaoCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.ORCID 0000-0003-1942-8309
Mao-Ping SongCollege of Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450001, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pyridine derivatives are valuable biologically active compounds, materials, and ligands; however, traditional methods for site-selective direct functionalization are often hindered by multistep procedures and harsh conditions. Herein, we report the general and efficient electroreductive C4 alkylation of pyridine derivatives with various alkyl bromides with high regioselectivity and good yields. The addition of chlorotrimethylsilane facilitated the in situ formation of an

Identifiers

PMID41270173
PMCPMC12637309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.