Evidence map›Paper›PMID 41270166›Full record

ArticleScience advances2025

Antigen-specific B cell response regulation by IL-10-producing tolerogenic dendritic cells.

Konstantina Morali, Juulke Steuten, Fabio Russo, Francesca Romana Santoni de Sio, Charlotte Menage, Valentina Consoli, Andrea Annoni, Silvia Iaia, S Marieke van Ham, Anja Ten Brinke and 1 more

Abstract read
In one paragraph

Article in Science advances, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Marine drugs · 2026
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Konstantina MoraliSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.ORCID 0000-0002-5359-7360
Juulke SteutenSanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.
Fabio RussoSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.ORCID 0000-0001-5280-5677
Francesca Romana Santoni de SioSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.ORCID 0000-0002-6522-0499
Charlotte MenageSanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0009-0009-7447-1212
Valentina ConsoliSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.
Andrea AnnoniSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.ORCID 0000-0002-8541-2578
Silvia IaiaSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.
S Marieke van HamSanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0000-0003-1999-9494
Anja Ten BrinkeSanquin Research and Landsteiner Laboratory, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam, Netherlands.ORCID 0000-0002-0135-7496
Silvia GregoriSan Raffaele Telethon Institute for Gene Therapy (SR-Tiget), Milan, Italy.ORCID 0000-0002-3517-9683

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

B cells regulate immune responses via antibody production and antigen (Ag) presentation. Although B cell depletion is used therapeutically, it may be associated with side effects, highlighting the need for alternative B cell-targeted approaches. While tolerogenic dendritic cells (tolDC) are known to modulate T cell responses, their impact on B cells is poorly defined. We show that IL-10-producing tolDC (DC

Indexed as

AntigensB-LymphocytesDendritic CellsImmune ToleranceInterleukin-10AnimalsAntigen PresentationCell DifferentiationCell ProliferationHumansLymphocyte ActivationMiceT-LymphocytesAntigensInterleukin-10

Identifiers

PMID41270166
PMCPMC12637295

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.