ArticlePloS one2025
Minimally invasive steam-assisted drug delivery with ICG fluorescence guidance for primary malignant bone tumors and evaluation of clinical applicability.
Article in PloS one, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
backgroundMalignant bone tumors are rare cancers with a poor prognosis, often causing severe pain and pathological fractures that substantially reduce patients' quality of life. Conventional cementoplasty can inhibit tumor cell proliferation but is limited by insufficient drug diffusion. To address this, we developed a minimally invasive drug delivery system utilizing high-temperature, high-pressure steam with integrated sensing and real-time temperature monitoring.
methodsA drug delivery system consisting of a water tank, pump, and steam generator was designed and fabricated. The system was equipped with a monitoring unit capable of real-time temperature measurement and control.
resultsLarge-animal experiments were conducted to evaluate the feasibility and distribution of steam injection in the femur. The procedure increased bone site temperatures to 48.8°C, as confirmed by fluorescence imaging. DISCUSSION: High-temperature steam successfully reached the target tissue; however, additional research is required to minimize collateral damage to normal bone. Future studies should focus on enhancing practicality by refining steam pressure and temperature control, optimizing nozzle design, and miniaturizing the device.
conclusionThe proposed steam-based drug delivery system achieved broader tissue distribution than conventional methods, demonstrating potential as a novel treatment strategy for metastatic bone tumors. Further preclinical studies are warranted to support its clinical translation.
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