Evidence map›Paper›PMID 41269904›Full record

ArticleRedox report : communications in free radical research2025

Ecm19 coordinates mitochondrial fission and cellular redox homeostasis.

Tiantian Chen, Sisi Lei, Haomin Qiu, Dan Zhao, Cuimei Hu, Yi Li, Xueya Zhao, Tiantian Tang, Jiaxin Deng, Zengyi Huang and 3 more

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Article in Redox report : communications in free radical research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Tiantian ChenSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Sisi LeiSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Haomin QiuSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Dan ZhaoSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Cuimei HuSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Yi LiSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Xueya ZhaoCollege of Artificial Intelligence Medicine, Chongqing Medical University, Chongqing, People's Republic of China.
Tiantian TangSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Jiaxin DengChongqing Academy of Animal Sciences, Chongqing, People's Republic of China.
Zengyi HuangMitomedical Laboratory of Children's Hospital, Chongqing Medical University, Chongqing, People's Republic of China.
Xianwen DongChongqing Academy of Animal Sciences, Chongqing, People's Republic of China.
Yu HouSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Xudong DuanSchool of Basic Medical Sciences, Chongqing Medical University, Chongqing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMitochondrial dynamics are tightly coupled with cellular redox homeostasis; however, the underlying regulatory mechanisms remain poorly defined.

methodsWe constructed yeast mutants and evaluated mitochondrial function, morphology, and redox states using growth assays, fluorescence imaging, and flow cytometry. RNA sequencing, RIP assays, and RT-qPCR were applied to identify Ecm19p target genes.

resultsDeletion of

conclusionEcm19 collaborates with Mdv1 and Caf4 to promote mitochondrial fission and post-transcriptionally represses

Indexed as

MitochondriaMitochondrial DynamicsMitochondrial ProteinsSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCatalaseHomeostasisOxidation-ReductionReactive Oxygen SpeciesCatalaseMitochondrial ProteinsReactive Oxygen SpeciesSaccharomyces cerevisiae ProteinsCAF4cellular redoxCTA1ECM19MDV1Mitochondrial fissionMitochondrial fusionTSA2

Identifiers

PMID41269904
PMCPMC12642899

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.