Evidence map›Paper›PMID 41269787›Full record

ArticleCancer reports (Hoboken, N.J.)2025

Assessment of Active Cytomegalovirus (CMV) and Epstein-Barr Virus (EBV) Infections and Patient Reported Fatigue in Ovarian Cancer Survivors.

Xuan Li, Katherine Brown, Kate Honeyfield, Devon Hunter-Schlichting, Morgan Gruner, Mark Blackstad, Mark R Schleiss, Deanna Teoh, Melissa A Geller, Heather H Nelson and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer reports (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xuan LiObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.
Katherine BrownObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0009-0006-7019-1633
Kate HoneyfieldObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.
Devon Hunter-SchlichtingEpidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2986-9602
Morgan GrunerObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0001-6796-9674
Mark BlackstadPediatric Infectious Diseases, University of Minnesota, Minneapolis, Minnesota, USA.
Mark R SchleissPediatric Infectious Diseases, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-2108-9433
Deanna TeohObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-1931-1445
Melissa A GellerObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4591-620X
Heather H NelsonEpidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-1901-9513
Rachel I VogelObstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-0149-8464

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Timothy C. Hallstrom · 1998 to 2026
$100.4M
University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UM1TR004405 · NCATS · UNIVERSITY OF MINNESOTA · PI Bruce R Blazar, Damien A Fair · 2023 to 2026
$30.8M
National Institute of Child Health and Human Development R01 HD099866NCATS NIH HHS UM1 TR004405NCATS NIH HHS UM1TR004405NCI NIH HHS P30 CA077598NCI NIH HHS P30 CA77598NICHD NIH HHS L50 HD099866United States Department of Defense OC180211 W81XWH-19-1-0014United States Department of Defense OC180392 W81XWH-19-1-0013
6 · The paper itself

Abstract

backgroundFatigue is a common symptom reported by individuals treated for ovarian cancer. The objective of this study was to determine whether fatigue following chemotherapy for ovarian cancer is related to biomarkers of active cytomegalovirus (CMV) or Epstein-Barr virus (EBV) infection.

methodsWe conducted a cross-sectional study among individuals diagnosed with ovarian, primary peritoneal, or fallopian tube cancer in Minnesota who had completed frontline chemotherapy, irrespective of current treatment status. Participants completed a survey and provided a blood sample. The primary exposures of interest were active CMV or EBV infections, determined by measuring CMV and EBV DNA levels in plasma (DNAemia). We also assessed serology-based markers of CMV infection and quantified levels of high-sensitivity C-reactive protein (hsCRP), as a biomarker of systemic inflammation. Symptoms of fatigue were self-reported using the Fatigue Symptom Inventory. We examined associations between fatigue symptoms and CMV and EBV by infection status, with and without inflammation, using two-sided t-tests and multivariable linear regression models accounting for confounding factors.

resultsAmong the 160 eligible participants, 64 (40.0%) demonstrated CMV DNAemia+, 56 (35.0%) had EBV DNAemia+, and 32 (20.0%) were positive for both. There were no significant associations between CMV or EBV DNAemia and fatigue. Similarly, CMV IgG and hsCRP status, alone or combined with CMV status, were not associated with fatigue scores.

conclusionWe did not observe associations between CMV DNAemia, EBV DNAemia, or hsCRP and fatigue in this survivor population. Further investigation is needed to identify causes and indicators of cancer-related fatigue following treatment for ovarian cancer.

Indexed as

Cancer SurvivorsCytomegalovirus InfectionsEpstein-Barr Virus InfectionsFatigueOvarian NeoplasmsAdultAgedC-Reactive ProteinCross-Sectional StudiesCytomegalovirusDNA, ViralFemaleHerpesvirus 4, HumanHumansMiddle AgedMinnesotaC-Reactive ProteinDNA, Viralcancercytomegalovirus (CMV)Epstein–Barr virus (EBV)fatigueinflammationsurvivorship

Identifiers

PMID41269787
PMCPMC12637270

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.