Evidence map›Paper›PMID 41269754›Full record

ArticleeLife2025

Peripheral glia and neurons jointly regulate activity-induced synaptic remodeling at the

Yen-Ching Chang, Yi-Jheng Peng, Joo Yeun Lee, Annie Wen, Karen T Chang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. The Repair Manual of a Fruit Fly Brain.International journal of molecular sciences · 2026
    Review
  2. microPublication biology · 2026
    Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Yen-Ching ChangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Yi-Jheng PengZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Joo Yeun LeeZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0001-6616-5594
Annie WenZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.
Karen T ChangZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, United States.ORCID https://orcid.org/0000-0001-7619-8170

Funding

Role of DYRK1A/MNB in Synaptic growth and functionR01NS080946 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KAREN T CHANG · 2013 to 2026
$5.0M
Molecular mechanisms underlying activity-induced synaptic remodelingR01NS102260 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHANG, KAREN T · 2018 to 2022
$2.2M
NINDS NIH HHS R01 NS080946NINDS NIH HHS R01NS080946NINDS NIH HHS R01 NS102260NINDS NIH HHS R01NS102260
6 · The paper itself

Abstract

In the nervous system, reliable communication depends on the ability of neurons to adaptively remodel their synaptic structure and function in response to changes in neuronal activity. While neurons are the main drivers of synaptic plasticity, glial cells are increasingly recognized for their roles as active modulators. However, the underlying molecular mechanisms remain unclear. Here, using

Indexed as

Drosophila melanogasterNeurogliaNeuromuscular JunctionNeuronal PlasticityNeuronsSynapsesAnimalsDrosophilaDrosophila ProteinsSignal TransductionDrosophila ProteinsD. melanogasterneuron–glia interactionsneuroscienceperipheral gliasynaptic plasticity

Identifiers

PMID41269754
PMCPMC12638043

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.