ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2026
Neonatal hyperoxia exposure does not exacerbate hypertension programmed by maternal obesity.
Jussara M do Carmo, John E Hall, Xuemei Dai, Emily Ladnier, Zhen Wang, Alan J Mouton, Alexandre A da Silva
Abstract read
In one paragraphArticle in American journal of physiology. Regulatory, integrative and comparative physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
7 authors.
Jussara M do CarmoDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0003-0471-0512 John E HallDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Xuemei DaiDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Emily LadnierDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.
Zhen WangDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0002-8028-8942 Alan J MoutonDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0001-5973-3071 Alexandre A da SilvaDepartment of Physiology and Biophysics, Mississippi Center for Obesity Research, Cardiorenal and Metabolic Diseases Research Center, University of Mississippi Medical Center, Jackson, Mississippi, United States.ORCID 0000-0003-4504-0607 Funding
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2MThe role of leptin in autoimmune-associated hypertensionP20GM104357 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI TAYLOR, ERIN BASSFORD · 2013 to 2022
$23.4MPilot Projects ProgramP30GM149404 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI DAVID E STEC · 2023 to 2026
$6.3MCardiac protective mechanisms of melanocortin system activationR01HL163076 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Jussara M. Do Carmo, Alexandre Alves da Silva · 2023 to 2026
$2.3MLong-term consequences of parental obesity on developmental programming of cardiorenal diseases in offspringR01DK121411 · NIDDK · UNIVERSITY OF MISSISSIPPI MED CTR · PI DO CARMO, JUSSARA M. · 2019 to 2021
$818kHHS | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL163076HHS | NIH | National Institute of General Medical Sciences (NIGMS) P20GM104357HHS | NIH | National Institute of General Medical Sciences (NIGMS) P30GM149404HHS | NIH | National Institute of General Medical Sciences (NIGMS) U54GM115428HHS | NIH | NIDDK | Division of Diabetes, Endocrinology, and Metabolic Diseases (DEM) DK121411NHLBI NIH HHS R01 HL163076NIDDK NIH HHS R01 DK121411NIGMS NIH HHS P20 GM104357NIGMS NIH HHS P30 GM149404NIGMS NIH HHS U54 GM115428
6 · The paper itselfAbstract
Maternal obesity increases the risk of preterm delivery and rapid transition of offspring from a hypoxemic environment to a normal or elevated oxygen environment, especially if the baby receives oxygen therapy. Maternal obesity may also increase offspring risk of developing hypertension. Thus, we examined whether neonatal hyperoxia (HO) leads to elevated blood pressure (BP) in offspring from lean mothers and exacerbates adverse impact of maternal obesity on offspring BP regulation. Male and female Sprague-Dawley offspring from lean and high-fat diet-fed obese mothers (
Indexed as
Blood PressureHyperoxiaHypertensionObesityPregnancy in ObesityPrenatal Exposure Delayed EffectsAnimalsAnimals, NewbornDisease Models, AnimalFemaleHeart RateMalePregnancyRats, Sprague-Dawleyblood pressure regulationcardiac functionheart ratehyperoxiaoffspring
Identifiers
PMID41269706
PMCPMC12797189
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