Evidence map›Paper›PMID 41269660›Full record

ArticleClinical journal of gastroenterology2026

A case of spontaneous regression of primary hepatic diffuse large B-cell lymphoma.

Tomohiro Ida, Hiroshi Takahashi, Katsutoshi Sugimoto, Tatsuya Kakegawa, Hirohito Takeuchi, Maki Tanigawa, Toshitaka Nagao, Takao Itoi

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tomohiro IdaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan. iden5f@yahoo.co.jp.
Hiroshi TakahashiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Katsutoshi SugimotoDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Tatsuya KakegawaDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Hirohito TakeuchiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.
Maki TanigawaDepartment of Human Pathology, Tokyo Medical University, Tokyo, Japan.
Toshitaka NagaoDepartment of Human Pathology, Tokyo Medical University, Tokyo, Japan.
Takao ItoiDepartment of Gastroenterology and Hepatology, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, 160-0023, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a rare case of spontaneous regression of primary hepatic diffuse large B-cell lymphoma (DLBCL) in an 89-year-old man. A 12 cm solitary hepatic mass was found in the anterior and medial segments. Contrast-enhanced CT showed a hypovascular solid tumor. Serologic markers including hepatitis B virus, hepatitis C virus, human immunodeficiency virus, alpha-fetoprotein, protein induced by vitamin K absence or antagonist-II, carbohydrate antigen 19-9, and carcinoembryonic antigen were negative, but soluble interleukin-2 receptor was elevated. Ultrasound-guided liver biopsy confirmed DLBCL, and the diagnosis of primary hepatic lymphoma was established based on Caccamo's criteria. The patient declined chemotherapy or radiotherapy due to age and preference, and was observed without treatment. Initially, the tumor grew slightly, but later imaging showed spontaneous regression without intervention. No recurrence or progression was observed during 15 months of follow-up. The regression may have been triggered by an immune response, possibly induced by biopsy-related stimulation. Primary hepatic lymphoma is extremely rare, accounting for 0.07% of malignant liver tumors, and spontaneous regression of untreated DLBCL is exceedingly uncommon. This case highlights the potential role of immune-mediated mechanisms in spontaneous tumor regression and supports careful observation as a possible management strategy in select elderly patients with primary hepatic lymphoma.

Indexed as

Liver NeoplasmsLymphoma, Large B-Cell, DiffuseNeoplasm Regression, SpontaneousAged, 80 and overHumansMaleRemission, SpontaneousTomography, X-Ray ComputedDiffuse large B-cell lymphomaMalignant lymphomaNeedle biopsyPrimary hepatic lymphomaSpontaneous regression

Identifiers

PMID41269660

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