Evidence map›Paper›PMID 41269654›Full record

ReviewEuropean geriatric medicine2026

Delirium: a modifiable risk factor for dementia.

Barbara C van Munster, Fijanne Strijkert, Monika Trzpis, Arjen J C Slooter, Mark van den Boogaard, Thomas H Ottens, DELIER-NL: the Dutch Interdisciplinary Delirium Network

Abstract readReview
PubMed Publisher
In one paragraph

Review in European geriatric medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Barbara C van MunsterUniversity Medical Center Groningen, Alzheimer Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0001-6056-7795
Fijanne StrijkertUniversity Medical Center Groningen, Alzheimer Center Groningen, University of Groningen, Groningen, The Netherlands. f.strijkert@umcg.nl.ORCID http://orcid.org/0000-0002-7709-0310
Monika TrzpisUniversity Medical Center Groningen, Alzheimer Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID http://orcid.org/0000-0003-3094-1090
Arjen J C SlooterDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0003-0804-8378
Mark van den BoogaardDepartment of Intensive Care Medicine, Radboud University Medical Center Nijmegen, Radboud University, Nijmegen, The Netherlands.ORCID http://orcid.org/0000-0003-4233-2903
Thomas H OttensDepartment of Intensive Care Medicine, University Medical Center Utrecht, Utrecht University, Utrecht, The Netherlands.ORCID http://orcid.org/0000-0001-6861-5755
DELIER-NL: the Dutch Interdisciplinary Delirium Network

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

background and purposeWith the increasing global burden of dementia, it is crucial to address modifiable factors that contribute to the development and progression of dementia. In this article, we provide evidence from various types of research that delirium is an independent modifiable risk factor for dementia.

methodsWe synthesized recent literature concerning epidemiological, neuropsychological, and neurobiological research on the association between delirium and dementia.

resultsThe body of literature provides evidence for an increased risk of cognitive impairment and dementia after delirium, even when no pre-existing cognitive impairment is objectified. Delirium and dementia share neurobiological pathways, involving, e.g., neuroinflammation, neuronal injury, dysregulated cerebral metabolism, and disintegration of brain networks. Multicomponent non-pharmacological interventions that reduce the risk of subsequent cognitive decline are feasible.

conclusionsAs of yet, ample evidence exists that delirium is an independent modifiable risk factor for dementia. More research is needed to further elucidate neurobiological and protective mechanisms underlying this association.

Indexed as

Cognitive DysfunctionDeliriumDementiaHumansRisk FactorsCognitive impairmentDeliriumDementiaModifiable risk factorsNeurobiological pathwaysPrevention

Identifiers

PMID41269654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.