Evidence map›Paper›PMID 41269520›Full record

ReviewAdvances in therapy2026

Recent Advancements in Non-surgical Approaches for the Management of Delayed Union and Nonunion in Long Bone Fractures of the Extremities: A Review.

Renhao Zhang, Qidai Cai, Jizhi Ma, Ming Zhong, Fengyue Guo, Yipeng Yang, Kai Meng, Jiang Shao, Zhengze Zhang

Abstract readReview
PubMed Publisher
In one paragraph

Review in Advances in therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renhao Zhang *The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan City, 250000, Shandong Province, China.
Qidai Cai *The First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan City, 250000, Shandong Province, China.
Jizhi MaThe First Clinical Medical School, Guangzhou University of Chinese Medicine, Guangzhou City, 510405, Guangdong Province, People's Republic of China.
Ming ZhongDepartment of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou City, 510405, Guangdong Province, People's Republic of China.
Fengyue GuoThe First Clinical Medical College, Shandong University of Traditional Chinese Medicine, Jinan City, 250000, Shandong Province, China.
Yipeng YangShuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai City, 201203, People's Republic of China.
Kai Meng *Orthopaedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan City, 250000, Shandong Province, China. sdmengkai2016@163.com.
Jiang Shao *Orthopaedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan City, 250000, Shandong Province, China. shaoj18@163.com.
Zhengze Zhang *Orthopaedics, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, No. 16369, Jingshi Road, Jinan City, 250000, Shandong Province, China. drzhangzhengze@163.com.ORCID 0009-0006-7939-6731

Funding

Project of Chongqing Natural Science Foundation 2024NSCQ-MSX3942
6 · The paper itself

Abstract

Delayed union and nonunion of long bone fractures are common clinical complications, especially among patients suffering from chronic diseases like osteoporosis and diabetes. Although traditional surgical procedures are commonly applied, they are characterized by numerous problems, such as the need for secondary surgical procedures and the increased risk of complications. On the other hand, non-surgical therapy presents an attractive option since it can avoid the hazards of surgery, prevent complications, and help lower medical expenses. This practice has been gaining interest in recent times. This article will summarize the most recent developments in the non-surgical treatment field for delayed union and nonunion of long bone fractures, which will help improve clinical practice and the discipline of regenerative medicine.

Indexed as

Fractures, BoneFractures, UnunitedFracture HealingHumansDelayed unionLong bone fracturesNon-surgicalNonunion

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.