ArticleObesity surgery2026
Reduced Incidence of QTc Prolongation Following Metabolic and Bariatric Surgery in Female Patients: A Retrospective Cohort Study.
Article in Obesity surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 citing paper in PubMed.
- Elevated preoperative red cell distribution width and incident anemia after metabolic and bariatric surgery: a cohort study.Frontiers in nutrition · 2026Article
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4 authors.
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Abstract
backgroundAlthough metabolic and bariatric surgery (MBS) is an established treatment for obesity, its effects on cardiac electrophysiology remain poorly characterized. This study investigated whether MBS was associated with a reduced risk of QTc interval prolongation in female patients with severe obesity.
methodsThis retrospective cohort study utilized the TriNetX database to identify female adults with body mass index ≥ 40 kg/m² who underwent laparoscopic surgery between 2010 and 2023. Patients were stratified into MBS (sleeve gastrectomy or gastric bypass) and control groups (other laparoscopic procedures). We performed 1:1 propensity score matching based on demographics, comorbidities, and laboratory parameters. The primary outcome was the incidence of QTc prolongation (≥ 460 ms) at one-year follow-up. Secondary analyses assessed outcomes at three months and three years to evaluate temporal trends. A prespecified subgroup analysis examined whether the effects differed by surgical technique.
resultsAmong 79,796 matched female patients (39,898 per group), MBS was associated with a significantly reduced QTc prolongation cumulative incidence within one year (0.33% vs. 0.77%; Hazard ratio [HR]: 0.41, 95% confidence interval [CI]: 0.33-0.50, p < 0.001). This association remained consistent across follow-up (HRs 0.47 at three months; 0.39 at three years). The association between procedure type and QTc prolongation differed in magnitude, with sleeve gastrectomy showing a lower HR than gastric bypass (0.34 vs. 0.61, p for subgroup difference = 0.005).
conclusionMBS confers a sustained three-year reduction in QTc prolongation risk in female patients with severe obesity, likely reflecting the cardiovascular benefits of weight loss and metabolic recovery, though individual contributions cannot be separated.
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