ArticleBrain informatics2025
Biotuner: A python toolbox integrating music theory and signal processing for harmonic analysis of physiological and natural time series.
Article in Brain informatics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundThe Biotuner Toolbox is an open-source Python toolbox for biosignals that integrates concepts from neuroscience, music theory, and signal processing. It introduces a harmonic perspective on physiological oscillations by applying musical constructs such as consonance, rhythm, and scale construction.
methodsThe core biotuner_object processes neural, cardiac, and auditory time series, providing a unified interface for extracting spectral peaks, computing harmonicity metrics, and supporting downstream analyses. Companion modules extend harmonic analyses across temporal (time-resolved harmonicity), spatial (harmonic connectivity), and spectral (harmonic spectrum) dimensions.
resultsBiotuner identifies harmonic structure across different biosignals, revealing significant variations in harmonicity between physiological states. Specifically, the toolbox extracts spectral peaks from complex signals using multiple algorithms, ensuring robust peak detection under varying signal-to-noise ratios. Moreover, we show how harmonicity metrics change across distinct sleep stages and capture variations in the slopes of the aperiodic (1/f) component of the power spectrum.
conclusionBiotuner provides an extensible framework that unifies music-theoretic constructs with biosignal processing, enabling hypothesis-driven analyses for researchers and, in parallel, creative exploration of complex natural patterns for artists.
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