ArticleEJNMMI reports2025
18 F-PSMA PET/CT reveals occult pericardial inflammation.
Article in EJNMMI reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
18F-PSMA PET/CT is widely utilized for the detection and staging of prostate cancer due to its high affinity for prostate-specific membrane antigen (PSMA), which is overexpressed in malignant prostate tissue. PSMA ligands have also been shown to accumulate in non-prostatic tissues under certain pathological conditions, including inflammation. We report a case of inci dentally detected subclinical pericardial inflammation in a patient undergoing prostate cancer staging with 18F-PSMA PET/CT imaging. A 61-year-old male with histologically confir med, organ-confined prostate adenocarcinoma (Gleason score 7, Grade Group 2) underwent 18F-PSMA PET/CT clinically indicated for staging prior to radical prostatectomy. While no evidence of metastatic disease was found, the scan revealed mildly increased PSMA uptake along the pericardium with a small associated effusion. The patie nt had no clinical signs or symptoms of pericarditis, and comprehensive cardiac, infectious, and rheumatologic workup was unremarkable. Conservative management was pursued, and follow-up demonstrated resolution of the effusion with no clinical sequelae. Th is case illustrates that 18F-PSMA PET/CT, although performed for prostate cancer staging, may incidentally detect findings such as subclinical pericardial inflammation, emphasizing the importance of careful evaluation of extra-prostatic uptake. Further res earch is warranted to explore its potential role in identifying subclinical inflammatory conditions beyond oncology.
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