Evidence map›Paper›PMID 41269379›Full record

ArticleClinical oral investigations2025

Salivary parameters and dental caries in normoglycemic and hyperglycemic adults: findings from a cross-sectional analysis.

Rafaella Cristhina Rego Marques, Joana Rodrigues da Silva, Larisse Santos Mendonça Alves, Bruna Leis Endres, Pedro Chagas Pereira-Neto, Letícia Gonçalves Reis, Carlos Daniel Correa de Oliveira Melo, Eduarda Carvalho Leite, Luana Severo Alves, Naile Dame-Teixeira

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Article in Clinical oral investigations, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Rafaella Cristhina Rego MarquesSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Joana Rodrigues da SilvaSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Larisse Santos Mendonça AlvesSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Bruna Leis EndresSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Pedro Chagas Pereira-NetoSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Letícia Gonçalves ReisSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Carlos Daniel Correa de Oliveira MeloSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Eduarda Carvalho LeiteSchool of Health Sciences, University of Brasilia, Brasília, Brazil.
Luana Severo AlvesSchool of Dentistry, Federal University of Santa Maria, Santa Maria, Brazil.
Naile Dame-TeixeiraSchool of Health Sciences, University of Brasilia, Brasília, Brazil. nailedame@unb.br.ORCID 0000-0002-0490-0036

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo investigate the association between salivary parameters and the number of coronal and root caries lesions (caries extent), as well as to assess whether glycemic status is influencing this association. MATERIALS AND

methodsThis cross-sectional study included dentate adults aged ≥ 35 years. Sociodemographic, behavioral, general and oral health data were collected, as well as salivary parameters, such as flow, pH, buffering capacity, viscoelasticity, and concentration of calcium, glucose, phosphate, and urea. The outcomes were the number of coronal caries (total, active, cavitated) and root caries (total, active, root caries index). Unadjusted and adjusted Poisson regression models were applied to estimate rate ratio (RR) and 95% confidence intervals (CI).

resultsThe average of coronal caries extent was significantly higher in individuals with hyperglycemia. Phosphate stood out as a factor associated with coronal caries, both active lesions and cavitated lesions. Buffering capacity was also associated with coronal cavitated caries lesion. Regarding root caries, pH and calcium were associated with the total number of root lesions while pH and urea were associated with the number of active root lesions. Glucose levels and viscoelasticity were also associated with root caries.

conclusionsQualitative salivary parameters were associated with the number of caries lesions differently for coronal and root caries, even after adjusting for the glycemic status. CLINICAL RELEVANCE: Association between caries and hyperglycemia should consider salivary parameters beyond flow, along with both caries lesion extent and activity outcomes.

Indexed as

Dental CariesHyperglycemiaSalivaAdultAgedCross-Sectional StudiesFemaleHumansHydrogen-Ion ConcentrationMaleMiddle AgedViscosityCaries activityDental cariesHyperglycemiaRoot cariesSalivaSalivary parametersType 2 diabetes

Identifiers

PMID41269379

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