Evidence map›Paper›PMID 41269367›Full record

ReviewNeurosurgical review2025

Upfront radiation for small, nongrowing vestibular schwannomas: a call for caution.

Nicholas S Andresen, Robert J Macielak, Desi P Schoo, Yin Ren, Kyle C Wu, Daniel M Prevedello, Oliver F Adunka, William H Saunders

Abstract readReview
PubMed Publisher
In one paragraph

Review in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Nicholas S AndresenDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA.
Robert J MacielakDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA.
Desi P SchooDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA.
Yin RenDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA.
Kyle C WuDepartment of Neurosurgery, The Ohio State University, Columbus, OH, USA.
Daniel M PrevedelloDepartment of Neurosurgery, The Ohio State University, Columbus, OH, USA.
Oliver F AdunkaDepartment of Otolaryngology-Head and Neck Surgery, The Ohio State University, Columbus, OH, USA. oliver.adunka@osumc.edu.
William H SaundersDivision of Otology, Neurotology, & Cranial Base Surgery, Department of Otolaryngology - Head & Neck Surgery, The Ohio State University Wexner Medical Center, 915 Olentangy River Rd, Columbus, OH, 43212, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The management of small vestibular schwannomas (VS) with serviceable hearing remains controversial. While stereotactic radiosurgery (SRS) achieves high tumor control rates, its routine use for nongrowing, asymptomatic tumors may represent overtreatment. Decades of natural history data demonstrate that more than half of small or intracanalicular VSs remain radiographically stable for 10 years or longer, and many patients report high satisfaction with observation. Although SRS offers short-term hearing preservation, long-term outcomes show progressive decline, with fewer than half of patients maintaining serviceable hearing at five years and even fewer beyond a decade. Radiation also introduces potential late toxicities and complicates subsequent microsurgical salvage. Observation, by contrast, defers unnecessary intervention while preserving future treatment options and quality of life. For small, stable VSs, evidence supports a "wait-and-scan" strategy as the safest, most patient-centered initial management approach, reserving SRS or microsurgery for documented tumor progression or symptomatic deterioration.

Indexed as

Neuroma, AcousticRadiosurgeryHumansMicrosurgeryQuality of LifeTreatment Outcome

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.