ReviewNeurosurgical review2025
Upfront radiation for small, nongrowing vestibular schwannomas: a call for caution.
Review in Neurosurgical review, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The management of small vestibular schwannomas (VS) with serviceable hearing remains controversial. While stereotactic radiosurgery (SRS) achieves high tumor control rates, its routine use for nongrowing, asymptomatic tumors may represent overtreatment. Decades of natural history data demonstrate that more than half of small or intracanalicular VSs remain radiographically stable for 10 years or longer, and many patients report high satisfaction with observation. Although SRS offers short-term hearing preservation, long-term outcomes show progressive decline, with fewer than half of patients maintaining serviceable hearing at five years and even fewer beyond a decade. Radiation also introduces potential late toxicities and complicates subsequent microsurgical salvage. Observation, by contrast, defers unnecessary intervention while preserving future treatment options and quality of life. For small, stable VSs, evidence supports a "wait-and-scan" strategy as the safest, most patient-centered initial management approach, reserving SRS or microsurgery for documented tumor progression or symptomatic deterioration.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.