ArticleLasers in medical science2025
Comparative efficacy of fractional CO₂ laser combined with concentrated growth factor (CGF) for treating hypertrophic scars in rabbit ears.
Article in Lasers in medical science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
While fractional CO₂ laser and concentrated growth factor (CGF) have been individually applied in scar management, their combined therapeutic potential remains underexplored. This study aimed to evaluate the synergistic efficacy and underlying mechanisms of fractional CO₂ laser combined with CGF in a rabbit ear hypertrophic scar model, with a focus on inflammatory modulation and collagen remodeling. Hypertrophic scars were induced on both ears of six rabbits. The scars were divided into three groups: combined CO₂ laser + CGF, CO₂ laser + saline, and untreated control. Scar tissues were assessed via macroscopic observation, H&E staining, Masson trichrome staining, and immunohistochemistry for CD34, IL-6, and TGF-β1. The combined treatment group exhibited significantly improved scar appearance, collagen organization, and reduced microvessel density compared to both the laser-only and control groups. Immunohistochemical analysis revealed a marked downregulation of IL-6 and TGF-β1 in the combined group, indicating enhanced anti-fibrotic and anti-inflammatory effects. The combination of fractional CO₂ laser and CGF synergistically promotes scar regression through dual mechanisms of physical ablation and biological regulation. This approach represents a promising strategy for enhancing scar treatment outcomes, with potential for clinical translation.
Indexed as
Identifiers
41269366What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.