Evidence map›Paper›PMID 41269319›Full record

ArticleSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Factors affecting the condition and prognosis of patients with late-onset noninfectious pulmonary complications after allogeneic hematopoietic stem cell transplantation: a propensity score-matched study.

Ryota Hamada, Yohei Oshima, Susumu Sato, Yuji Yoshioka, Naoya Tanabe, Ayumi Otagaki, Tsugumi Asano, Akira Tamaki, Tadakazu Kondo, Junya Kanda and 2 more

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Article in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Ryota HamadaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan. e1923126@kuhp.kyoto-u.ac.jp.ORCID http://orcid.org/0000-0002-8547-5173
Yohei OshimaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.ORCID http://orcid.org/0000-0003-0680-4045
Susumu SatoDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-9626-1090
Yuji YoshiokaRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.ORCID http://orcid.org/0000-0002-3361-3757
Naoya TanabeDepartment of Respiratory Medicine, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-7481-0212
Ayumi OtagakiRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.
Tsugumi AsanoRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.ORCID http://orcid.org/0009-0002-3440-7282
Akira TamakiGraduate School of Rehabilitation Science, Hyogo Medical University, Kobe, Japan.ORCID http://orcid.org/0000-0003-4155-9380
Tadakazu KondoDepartment of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-8959-6271
Junya KandaDepartment of Hematology, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-6704-3633
Daisuke NakajimaDepartment of Thoracic Surgery, Graduate of School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0002-9761-2825
Ryosuke IkeguchiRehabilitation Unit, Kyoto University Hospital, Kyoto, Japan.ORCID http://orcid.org/0000-0003-4525-7849

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeLate-onset non-infectious pulmonary complications (LONIPCs) represent significant sequelae of hematopoietic stem cell transplantation (HSCT), contributing to elevated non-relapse mortality rates. A comprehensive understanding of systemic conditions and prognostic indicators is essential for enhancing supportive care following onset. This study aims to compare respiratory and physical function between patients with LONIPCs and healthy controls, and to identify prognostic factors that influence survival outcomes in patients with LONIPCs.

methodsThis study included 41 LONIPCs patients admitted to Kyoto University Hospital for lung transplant evaluation. A healthy control group comprised matched living lung transplant donors. Comparisons included respiratory function tests, 6-min walk distance (6MWD), and erector spinae muscle cross-sectional area (ESMA). Multivariate Cox regression analysis was used to identify prognostic factors.

resultsLONIPCs patients demonstrated significantly reduced respiratory function and 6MWD compared to healthy controls. ESMA was also significantly lower in the patient group. Multivariate Cox regression revealed that decreased knee extensor strength and reduced ESMA were significant predictors of overall survival in patients with LONIPCs.

conclusionImpairments in respiratory and physical function are evident in LONIPCs patients. Modifiable factors such as lower limb muscle strength and skeletal muscle mass, particularly ESMA, are associated with prognosis and should be prioritized in rehabilitation strategies to improve patient outcomes.

Indexed as

Hematopoietic Stem Cell TransplantationLung DiseasesAdultAgedCase-Control StudiesFemaleHumansMaleMiddle AgedMuscle StrengthPrognosisPropensity ScoreProportional Hazards ModelsRespiratory Function TestsWalk TestAllogeneic hematopoietic stem cell transplantationLate-onset non-infectious pulmonary complicationsPhysical functionPropensity score-match

Identifiers

PMID41269319

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.