ArticleAbdominal radiology (New York)2026
Ultrasound and MRI for pediatric Crohn's disease assessment: correlations of the MaRIA score and IBUS-SAS with endoscopic disease activity and optimal cutoff values.
Article in Abdominal radiology (New York), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo assess transmural damage in Crohn's disease (CD), magnetic resonance enterography (MRE, scored by the Magnetic Resonance Index of Activity, MaRIA) and intestinal ultrasound (IUS, scored by the International Bowel Ultrasound Segmental Activity Score, IBUS-SAS) are used. This study examined their correlation with the Crohn's Disease Endoscopic Index of Severity (CDEIS) in children with CD.
methodsThis was a retrospective analysis of children with new-onset CD who were treated from 2017 to 2022 at Zhejiang University Children's Hospital. The patients underwent IUS, MRE, and colonoscopy. MaRIA, IBUS-SAS, and CDEIS were assessed across intestinal segments. Correlation analyses were performed separately for the total score (all segments), as well as the terminal ileum score (terminal ileum segments) and the colon score (all colorectal segments). Nonnormally distributed data were analysed using Spearman's rank correlation coefficient.
resultsForty-eight children were included in this study. The total MaRIA and total IBUS-SAS scores were positively correlated with the CDEIS value (r = 0.334 and r = 0.328, both p < 0.05). In the colorectal region, the Spearman's rank correlation coefficient between the MaRIA score and the CDEIS value was 0.345 (P < 0.05), and that between the IBUS-SAS score and the CDEIS value was 0.501 (P < 0.05). However, in the terminal ileum, neither the IBUS-SAS nor the MaRIA score was significantly correlated with the CDEIS value. In the validation of the total IBUS-SAS, the AUC was 0.655 (95% CI 0.496-0.814), with an optimal cutoff value to predict endoscopically moderate active disease (CDEIS value ≥ 9) of 55.5.
conclusionsBoth the MaRIA and the IBUS-SAS correlate with CDEIS in new-onset pediatric CD. IBUS-SAS > 55.5 indicates moderate activity. IUS can serve as an alternative to MRE for disease activity assessment when MRE is not viable.
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