Observational studyGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2026
Ethnic comparison of MacTel over 5 years follow up.
Observational study in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo compare long-term structural disease progression in type 2 macular telangiectasia (MacTel) between Indian and Caucasian populations using a novel optical coherence tomography-based staging system structured around retinal layer involvement.
methodsThis retrospective, observational, dual-center cohort study included 49 eyes from 30 Caucasian and 109 eyes from 55 Indian patients with type 2 MacTel. All patients had a minimum of 5 years follow-up. Disease severity was staged as early, intermediate, or advanced based on predefined OCT features involving the inner retina, outer retina, and presence of neovascularization. Progression was defined as a shift to a higher stage. Kaplan-Meier survival analysis, log-rank test, and Cox proportional hazard models were used to evaluate progression and associated risk factors.
resultsAt baseline, both groups had similar stage distributions (p = 0.451). Over the follow-up period, 82% of Caucasian and 81% of Indian eyes showed no disease progression. Median time to progress from early to intermediate stage was 32 months in Caucasians and 36 months in Indians (p = 0.847). Progression to advanced stage occurred after 51 and 69.5 months, respectively (p = 0.497). Survival analysis showed no significant differences in progression based on gender, ethnicity, or diabetes mellitus status.
conclusionStructural progression in type 2 MacTel is slow and comparable across Caucasian and Indian cohorts over long-term follow up. Further studies to compare the influence of systemic and environmental conditions across different ethnicities will help understand pathogenesis of MacTel.
Indexed as
Identifiers
41269264What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.