ArticleACS nano2025
Lipid Nanoparticle Library Screen Reveals Lymphatic Endothelial Cell-Targeting Lipid Nanoparticle for Delivering Vascular Endothelial Growth Factor C mRNA after Lymphatic Injury.
Article in ACS nano, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Lymphatic Endothelial Cells in Health and Disease.MedComm · 2026Review
- Tissue-specific gene delivery approaches.Bioengineering & translational medicine · 2026Review
- AI-Empowered Mechanomedicine for Cancer-Related Lymphedema.Research (Washington, D.C.) · 2026Review
Corrections and comments
- Update of
Authors and funding
14 authors.
Funding
Abstract
Dysfunction of the lymphatic system following injury, disease, or cancer treatment can lead to lymphedema, a debilitating condition with no cure. Advances in targeted therapy have shown promise for treating diseases where conventional therapies, including broad-spectrum chemotherapy, surgical interventions, and palliative care, have often failed to achieve durable responses. As lymphatic vessels have recently emerged as a therapeutic target, nucleic acid delivery via nanoparticles to lymphatic endothelial cells (LECs) has been studied utilizing lymphatic drainage; however, there are no approaches to modulate the chemical compositions of lipid nanoparticles (LNPs) to optimize LEC specificity. To identify an LNP that effectively delivers mRNA to LECs after intradermal (ID) injection, we screened a library of 150 LNPs in total spread out over 3 screening rounds. The 150 formulations had a variety of chemical compositions and were assessed for both self-assembly and delivery
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.