Evidence map›Paper›PMID 41269051›Full record

ArticleArchiv der Pharmazie2025

Investigation on LASSBio-1971 and LASSBio-1974 Cellular Cytotoxic Mechanism and Their Comparative DMPK Profile.

Manoel Oliveira de Moraes Junior, Gisele Barbosa, Caroline Marques Xavier da Costa, Raysa Magali Pillpe-Meza, Wesley Leandro de Gouveia, Daniel Nascimento do Amaral, Luis Gabriel Valdivieso Gelves, Stefan Laufer, Lídia Moreira Lima

Abstract readComparative Study
In one paragraph

Article in Archiv der Pharmazie, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Manoel Oliveira de Moraes JuniorNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0001-6354-1064
Gisele BarbosaNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.
Caroline Marques Xavier da CostaNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.
Raysa Magali Pillpe-MezaNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-5116-1539
Wesley Leandro de GouveiaNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.ORCID https://orcid.org/0009-0001-5269-2008
Daniel Nascimento do AmaralNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.
Luis Gabriel Valdivieso GelvesNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.ORCID https://orcid.org/0000-0002-6013-2879
Stefan LauferNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.
Lídia Moreira LimaNational Institute of Science and Technology of Pharmaceuticals and Medications (INCT-INOFAR), Federal University of Rio de Janeiro, Laboratory of Evaluation and Synthesis of Bioactive Substances (LASSBio), CCS, University City, Rio de Janeiro, Brazil.

Funding

This study was supported by Instituto Nacional de Ciência e Tecnologia de Fármacos e Medicamentos and Fundação Carlos Chagas Filho de Amparo à Pesquisa do Estado do Rio de Janeiro.
6 · The paper itself

Abstract

Due to the arising of clinically relevant resistant EGFR-related phenotype through innovative mechanisms, mainly EGFR

Indexed as

Antineoplastic AgentsCarcinoma, Non-Small-Cell LungLung NeoplasmsProtein Kinase InhibitorsAnimalsApoptosisCell Line, TumorCell ProliferationCell SurvivalDose-Response Relationship, DrugDrug Screening Assays, AntitumorErbB ReceptorsHumansMolecular StructureRatsStructure-Activity RelationshipAntineoplastic AgentsEGFR protein, humanErbB ReceptorsProtein Kinase InhibitorsDMPKEGFR inhibitorEGFR resistanceglutathione‐adductnon‐small cell lung cancer

Identifiers

PMID41269051
PMCPMC12637173

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.