ArticleAnnals of medicine2025
A machine-learning model to identify concurrent vascular disease in symptomatic patients with chronic obstructive pulmonary disease.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- A TabPFN-based prediction system for refractive error and dry eye comorbidity: a retrospective study using large-scale real-world data.Frontiers in cell and developmental biology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
AIM/
introductionChronic obstructive pulmonary disease (COPD) is a complex, heterogeneous syndrome often accompanied by vascular diseases that worsen prognosis and quality of life. This study aimed to develop a machine learning model to identify concurrent vascular diseases in symptomatic COPD patients. MATERIALS AND
methodsWe retrospectively analyzed data from 6,274 COPD patients treated between July 2010 and July 2018. Patients were randomly split into training and validation sets (7:3). After feature selection using LASSO regression, eight machine learning algorithms-including Logistic Regression, Random Forest, Gradient Boosting, Support Vector Machine, Neural Network, Convolutional Neural Network, AdaBoost, and Stacked Generalization (Stacking)-were applied to develop and validate predictive models. Performance was evaluated using AUC, calibration curves, and decision curve analysis (DCA).
resultsThe Stacking model achieved the highest AUC (0.867; 95% CI: 0.852-0.882), with 79.4% accuracy, 74.9% sensitivity, and 84.0% specificity. It also demonstrated excellent calibration and, on DCA, provided the highest net clinical benefit within the threshold probability range of 0.1-0.5. At a 0.2 threshold, the model could prevent approximately 35% of unnecessary interventions compared to a "treat-all" approach, while identifying about 75% of high-risk patients relative to a "treat-none" strategy.
conclusionsThe Stacking machine-learning model showed superior performance in identifying concurrent vascular disease among symptomatic COPD patients, offering strong discriminative ability, calibration, and clinical utility. It may serve as an effective decision-support tool to optimize diagnostic evaluation in this high-risk subgroup.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.