ArticleInternational endodontic journal2026
Copaiba Oil-Resin Reduces the Alveolar Bone Damage Triggered by Apical Periodontitis in Rats.
Article in International endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Toxicological evidence that methylmercury exposure amplifies bone destruction and systemic impact associated with apical periodontitis in rats.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThis study aimed to investigate the effects of copaiba oil-resin on induced apical periodontitis in rats. METHODOLOGY: A total of 24 male Wistar rats were divided equally into three groups (eight animals each): control (C), apical periodontitis (AP) and apical periodontitis with copaiba administration (AP + COP). The AP was induced by exposing the pulp chambers of the mandibular first molars to the oral environment. The openings were maintained for 28 days to allow lesion development. The AP + COP group received systemic administration of 200 mg/kg of copaiba oil-resin via intragastric gavage during the final 7 days of the AP induction period. The rats were then euthanised, and their hemimandibles were subjected to histopathological analysis to assess tissue preservation, histochemical staining with picrosirius red to evaluate collagen content, and microcomputed tomography to assess lesion volume and bone quality parameters. Statistical analyses were performed using a one-way ANOVA, followed by Tukey's post hoc test for parametric data and the Kruskal-Wallis test for nonparametric data. The results are expressed as mean and standard error of the mean for parametric tests, and median and interquartile deviation for the nonparametric test.
resultsThe findings showed that copaiba oil-resin reduced lesion volume compared to the untreated group (p = 0.0261), as well as reducing the space between the bone trabeculae found in the AP group (p = 0.0063). Additionally, copaiba oil-resin preserved the collagen fibres, which were more degraded in the untreated group (p = 0.0009). Histopathological analysis showed that copaiba oil-resin reduced tissue damage, preserving a significant area of alveolar bone surrounding the lesion.
conclusionsThese results indicate that copaiba oil resin has a promising adjunct therapeutic potential to reduce the bone loss caused by apical periodontitis and contribute to the maintenance of quality in the remaining bone.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.