Evidence map›Paper›PMID 41268909›Full record

ArticleeLife2025

PTBP1 depletion in mature astrocytes reveals distinct splicing alterations without neuronal features.

Min Zhang, Naoto Kubota, David Nikom, Ayden Arient, Sika Zheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Min Zhang *Division of Biomedical Sciences, University of California, Riverside, Riverside, United States.ORCID https://orcid.org/0009-0008-4105-057X
Naoto Kubota *Division of Biomedical Sciences, University of California, Riverside, Riverside, United States.ORCID https://orcid.org/0000-0003-0612-2300
David Nikom *Division of Biomedical Sciences, University of California, Riverside, Riverside, United States.ORCID https://orcid.org/0000-0003-2722-6002
Ayden ArientDepartment of Molecular, Cell and Systems Biology, University of California, Riverside, Riverside, United States.
Sika ZhengDivision of Biomedical Sciences, University of California, Riverside, Riverside, United States.ORCID https://orcid.org/0000-0002-0573-4981

Funding

The Role of NMD in Cortical Neural Progenitor CellsR01NS125276 · NINDS · UNIVERSITY OF CALIFORNIA RIVERSIDE · PI Sika Zheng · 2022 to 2026
$2.6M
National Institute of Health R01NS125276NINDS NIH HHS R01 NS125276
6 · The paper itself

Abstract

Astrocyte-to-neuron reprogramming via depletion of PTBP1, a potent repressor of neuronal splicing, has been proposed as a therapeutic strategy, but its efficacy remains debated. While some reported successful conversion, others disputed this, citing a lack of neuronal gene expression as evidence of failed reprogramming. This interpretation was further challenged, attributed to incomplete PTBP1 inactivation, fueling ongoing controversy. Mechanistic understanding of the conversion, or the lack thereof, requires investigating, in conjunction with lineage tracing, the effect of

Indexed as

AstrocytesHeterogeneous-Nuclear RibonucleoproteinsNeuronsPolypyrimidine Tract-Binding ProteinRNA SplicingAnimalsMiceMice, KnockoutHeterogeneous-Nuclear RibonucleoproteinsPolypyrimidine Tract-Binding ProteinPtbp1 protein, mousealternative splicingastrocytesmouseneurogenesisneuronal cell fateneurosciencePTBtransdifferentiation

Identifiers

PMID41268909
PMCPMC12638047

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.