Evidence map›Paper›PMID 41268905›Full record

ArticleeLife2025

HoxB-derived hoxba and hoxbb clusters are essential for the anterior-posterior positioning of zebrafish pectoral fins.

Morimichi Kikuchi, Renka Fujii, Daiki Kobayashi, Yuki Kawabe, Haruna Kanno, Sohju Toyama, Farah Tawakkal, Kazuya Yamada, Akinori Kawamura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Morimichi Kikuchi *Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Renka Fujii *Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Daiki Kobayashi *Division of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Yuki KawabeDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.ORCID https://orcid.org/0009-0008-9149-1605
Haruna KannoDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.ORCID https://orcid.org/0009-0008-5751-5992
Sohju ToyamaDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.ORCID https://orcid.org/0009-0006-8684-8345
Farah TawakkalDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.ORCID https://orcid.org/0009-0004-4438-7638
Kazuya YamadaDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.
Akinori KawamuraDivision of Life Science, Graduate School of Science and Engineering, Saitama University, Saitama, Japan.ORCID https://orcid.org/0000-0002-5618-7113

Funding

KAKENHI 18K06177KAKENHI 23K05790
6 · The paper itself

Abstract

Vertebrate paired appendages, such as the pectoral fins in fish and the forelimbs in tetrapods, arise at specific regions along the anterior-posterior axis of the body. Hox genes have long been considered prime candidates for determining the anteroposterior positioning of these paired appendages during development. Evidence from various model organisms, including mouse and chick, supports a role for Hox genes in limb positioning. However, despite extensive phenotypic analyses of numerous single and compound Hox knockout mice, clear genetic evidence for substantial defects in limb positioning has been limited, leaving questions unresolved. In a previous study, we generated seven distinct hox cluster-deficient mutants in zebrafish. Here, we provide genetic evidence that zebrafish

Indexed as

Animal FinsBody PatterningHomeodomain ProteinsMultigene FamilyZebrafishZebrafish ProteinsAnimalsGene Expression Regulation, DevelopmentalGenes, HomeoboxT-Box Domain ProteinsHomeodomain ProteinsT-Box Domain ProteinsZebrafish Proteinsanterior–posterior positioningdevelopmental biologyevolutionary biologyevolutionary origin of pectoral finHox clusterHox genespectoral finzebrafish

Identifiers

PMID41268905
PMCPMC12638046

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.