Evidence map›Paper›PMID 41268902›Full record

ArticleeLife2025

Functional characterization of neuropeptides that act as ligands for both calcitonin-type and pigment-dispersing factor-type receptors in a deuterostome.

Xiao Cong, Huachen Liu, Lihua Liu, Nayeli Escudero Castelán, Kite G E Jones, Michaela Egertová, Maurice R Elphick, Muyan Chen

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in eLife, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Xiao Cong *The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.ORCID https://orcid.org/0009-0001-4325-8015
Huachen Liu *The Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.ORCID https://orcid.org/0009-0003-3001-0840
Lihua LiuThe Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.
Nayeli Escudero CastelánSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.ORCID https://orcid.org/0000-0001-8443-9085
Kite G E JonesSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Michaela EgertováSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.
Maurice R ElphickSchool of Biological and Behavioural Sciences, Queen Mary University of London, London, United Kingdom.ORCID https://orcid.org/0000-0002-9169-0048
Muyan ChenThe Key Laboratory of Mariculture, Ministry of Education, Ocean University of China, Qingdao, China.ORCID https://orcid.org/0000-0002-3836-1325

Funding

Biotechnology and Biological Sciences Research Council BB/M001644/1Biotechnology and Biological Sciences Research Council BB/X001024/1National Natural Science Foundation of China 42276103
6 · The paper itself

Abstract

The calcitonin (CT) family of related peptides exerts diverse physiological effects in mammals via two G-protein-coupled receptors: CTR and the CTR-like receptor CLR. Phylogenetic analysis of CT-type signaling has revealed the presence of CT-type peptides and CTR/CLR-type proteins in both deuterostome and protostome invertebrates. Furthermore, experimental studies have demonstrated that in the protostome

Indexed as

NeuropeptidesReceptors, CalcitoninReceptors, G-Protein-CoupledAnimalsLigandsPhylogenySignal TransductionLigandsNeuropeptidesReceptors, CalcitoninReceptors, G-Protein-Coupledcalcitonincalcitonin receptorfeedinggrowthneurosciencepigment-dispersing factor receptorsea cucumber

Identifiers

PMID41268902
PMCPMC12638048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.