ReviewThe FEBS journal2026
A comprehensive overview of yeast libraries and their role in advancing cell biology.
Review in The FEBS journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- High-throughput editing boosts the construction of next-generation microbial cell factories.Synthetic and systems biotechnology · 2026Review
- Saccharomyces cerevisiae as a model for mammalian diseases.FEMS yeast research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Over the past two decades, genome-wide collections of mutants, or libraries, have revolutionized the fields of systems and cell biology by enabling systematic and high-throughput interrogation of gene and protein function. This has been especially prominent in the model yeast Saccharomyces cerevisiae. The unique genetic properties of yeast, combined with efficient genome engineering tools, have facilitated the creation of a large number of comprehensive collections of strains with targeted gene deletions, mutations, overexpressions, regulatable promoters, and protein tagging. These resources have enabled large-scale studies of cellular phenotypes, genetic and drug interactions, protein localization, protein-protein interactions, and much more. This review provides a comprehensive overview of the available systematic yeast libraries, highlighting their design, applications, and transformative impact on functional genomics. We detail how successive generations of libraries have addressed key challenges. Highlighting future applications, we discuss the potential integration of advanced fluorescent tools and machine learning approaches that promise to shape the next generation of libraries and establish yeast as a blueprint for systematic, dynamic, and predictive cell biology.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.