Evidence map›Paper›PMID 41268696›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

NDST3-Induced Epigenetic Reprogramming Reverses Neurodegeneration in Parkinson's Disease.

Yujung Chang, Yongwoo Na, Hyeonjoo Im, Garam Yang, Seungseon Yang, Hyun Soo Shim, Chunggoo Kim, GyeungYun Kim, Hyeok Ju Park, Hee Young Kim and 9 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yujung ChangLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
Yongwoo NaCenter for RNA Research, Institute for Basic Science, Seoul, 08826, South Korea.
Hyeonjoo ImLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
Garam YangLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
Seungseon YangLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
Hyun Soo ShimLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
Chunggoo KimLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.
GyeungYun KimBiology Department, Boston University, Boston, MA, 02215, USA.
Hyeok Ju ParkDatabase Laboratory, Department of Computer Science and Engineering, Dongguk University, Seoul, 04620, South Korea.
Hee Young KimDepartment of Physiology, College of Medicine, Yonsei University, Seoul, 03722, South Korea.
Seung Eun LeeResearch Animal Resource Center, Korea Institute of Science and Technology, Seoul, 02792, South Korea.
Wonwoong LeeCollege of Pharmacy, Woosuk University, Wanju, 55338, South Korea.
Yoon HaDepartment of Neurosurgery, College of Medicine, Yonsei University, Seoul, 03722, South Korea.
Sungho ParkDepartment of Chemistry, Yonsei University, Seoul, 03722, South Korea.
Jieun KimDepartment of Bio-Health Technology, College of Biomedical Science and Multi-dimensional Genomics Research Center, Kangwon National University, Chuncheon, 24341, South Korea.
Won-Young ChoCollege of Pharmacy, Woosuk University, Wanju, 55338, South Korea.
Woong SunDepartment of Anatomy, College of Medicine, Korea University, Seoul, 02841, South Korea.
Jong-Seo KimCenter for RNA Research, Institute for Basic Science, Seoul, 08826, South Korea.ORCID https://orcid.org/0000-0002-8909-8440
Junsang YooLaboratory of Regenerative Medicine for Neurodegenerative Disease, Stand Up Therapeutics Inc., Hannamdaero 98, Seoul, 04418, South Korea.ORCID https://orcid.org/0000-0002-9211-3963

Funding

Bio & Medical Technology Development Program of the National Research Foundation RS-2024-00440824Institute for Basic Science IBS-R008-D1Korean government
6 · The paper itself

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by the loss of dopaminergic neurons (DN) in the substantia nigra and disruption of cellular maintenance. Here, we demonstrate that NDST3-mediated epigenetic reprogramming halts neuronal degeneration and restores motor function in an animal model of PD. Following NDST3 administration, the DN and its associated circuits in the substantia nigra and striatum showed marked revitalization, accompanied by a considerable alleviation of PD-like motor deficits. Integrative single-cell and spatial RNA sequencing with CUT&RUN revealed that NDST3-driven reactivation of pathways is linked to neuronal survival, synaptic integrity, and steering of compromised cells toward a resilient phenotype. By recalibrating the epigenetic landscape, NDST3 promotes cellular maintenance and functional recovery in key motor circuits. These findings highlight NDST3's therapeutic potential as an epigenetic modulator of PD. These findings provide insights into the mechanisms underlying neuronal revitalization and highlight the potential of NDST3 as a novel agent for restoring brain function in neurodegenerative conditions.

Indexed as

Epigenesis, GeneticParkinson DiseaseAnimalsCellular ReprogrammingDisease Models, AnimalDopaminergic NeuronsHumansMaleMiceMice, Inbred C57BLSubstantia Nigracellular repaircell vitalizationepigenetic reprogrammingneurodegenerative diseaseParkinson's disease

Identifiers

PMID41268696
PMCPMC12970244

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.