ArticleAnnals of medicine2025
Relationship between long-term outcomes and optimal time interval in patients with bilateral synchronous multiple primary lung cancers: a multi-institutional cohort study.
Article in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Application of percutaneous cryoablation for pulmonary nodules and influence in pulmonary function.BMC cancer · 2026Article
- Prognostic implications of dominant lesion misidentification in multiple primary lung cancer.Translational lung cancer research · 2026Article
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Authors and funding
13 authors.
Funding
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Abstract
backgroundWith the advancement of diagnostic technology and changes in living environment, the incidence of synchronous multiple primary lung cancer (sMPLC) is increasing. This study aims to investigate the impact of surgical timing on clinical outcomes.
methodsThis multi-institutional cohort study retrospectively enrolled 901 patients with bilateral sMPLC who underwent two surgeries from January 2017 to December 2022. Three different subgroups were determined based on the time interval between the 1
resultsFor the entire cohort, the median follow-up time from the second surgery was 49.2 months. The clinical outcomes of patients in Group-II were more favourable than those in Group-I and Group-III (log-rank, OS,
conclusionsFor patients with bilateral sMPLC, our research identified a potential correlation between the interval of subsequent surgeries and patient prognosis. We suggest that an interval of 90 to 180 days between surgeries may be the most beneficial.
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