Evidence map›Paper›PMID 41268602›Full record

ArticleInternational journal of molecular medicine2026

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice.

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang

Abstract read
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In one paragraph

Article in International journal of molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan Chen *Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Hui-Min Zhao *Department of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Xiao-Lin Sun *Department of Neonatology, Maternal and Child Health Hospital of Linyi, Linyi, Shandong 276000, P.R. China.
Zhi-Xuan XingDepartment of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Sheng-Peng LiDepartment of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Shuai-Chao LiDepartment of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Ya-Xian WuDepartment of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Qing-Feng PangDepartment of Physiopathology, Wuxi School of Medicine, Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.
Jian-Feng HuangDepartment of Radiation Oncology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214122, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Intrauterine growth restriction (IUGR) is a leading cause of perinatal morbidity and mortality. Oxidative stress is a key factor in the pathogenesis of IUGR. The transcription factor nuclear factor erythroid 2‑related factor 2 (Nrf2) is a key regulator of the cellular antioxidant response. MOTS‑c, a 16‑amino acid peptide derived from the mitochondria, regulates oxidative stress related pathways. However, the effects of MOTS‑c on IUGR remain unclear. The present study aimed to investigate the role of MOTS‑c in hypoxia‑induced placental restriction and IUGR and its underlying mechanisms. Wild‑type and Nrf2 knockout (KO) maternal mice were exposed to hypoxia from gestational days 11 to 17.5 to establish the IUGR model. Human umbilical vein endothelial cells (HUVECs) were used for

Indexed as

Fetal Growth RetardationHypoxiaNF-E2-Related Factor 2PlacentaAnimalsDisease Models, AnimalFemaleHumansHuman Umbilical Vein Endothelial CellsMiceMice, Inbred C57BLMice, KnockoutOxidative StressPregnancyNfe2l2 protein, mouseNF-E2-Related Factor 2hypoxiaintrauterine growth restrictionMOTS‑cnuclear factor erythroid 2‑related factor 2placental injury

Identifiers

PMID41268602
PMCPMC12651125

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.