ArticleCancer innovation2025
Identification of Chondroitin Polymerizing Factor as a Biomarker for Colorectal Cancer by the Human Villi Development Model.
Article in Cancer innovation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Identification of Chondroitin Polymerizing Factor as a Biomarker for Colorectal Cancer by the Human Villi Development Model.Cancer innovation · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Emerging mounts of research support the ancestral theory of cancer, indicating that tumorigenesis and embryogenesis share many similar biological features, yet yield distinct outcomes. Gene co-expression networks underlie both embryonic development and tumorigenesis. We hypothesize that deviations in the gene interaction patterns in tumors compared to villi predispose to malignancy and worse prognosis. Methods: By constructing a gene co-expression network of villi and colorectal cancer (CRC) and conducting functional enrichment analysis to identify "off-track genes." Cox regression assessed prognostic significance, while tissue microarrays evaluated protein expression and progression. Additionally, mRNA sequencing of chondroitin polymerizing factor ( Results: We found that genes in villi and CRC have similar functions, but the genes that performed corresponding functions were not identical. Then, according to "off-track theory" and linear regression models, we obtained 24 genes whose aberrant expression was significantly associated with poor CRC survival. Notably, Conclusion: These findings validate that villi development can serve as a research model for tumorigenesis, and identify
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.