ReviewInnovation (Cambridge (Mass.))2025
Multiscale metabolic engineering in biological lignin valorization.
Review in Innovation (Cambridge (Mass.)), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Microbial Lignin Valorization to Protocatechuic Acid and Catechol: Biofunneling Pathways and Metabolic Engineering Strategies.Biomolecules · 2026Review
- Advancing lignocellulosic conversion though biosensor-enabled metabolic engineering.Green chemistry : an international journal and green chemistry resource : GC · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lignin, a natural and renewable aromatic polymer, serves as a plentiful source of aromatic building blocks for biomanufacturing. However, despite its potential, the bioconversion efficiency of lignin remains limited due to its inherently complex structure and the constraints of traditional metabolic engineering approaches. Synthetic biology-guided metabolic regulation offers a solution by coordinating intracellular resource allocation in ligninolytic strains, endowing their adaptation for industrial applications and promoting the sustainability of lignin-based bioeconomy. This review provides a comprehensive overview of multiscale metabolic regulation, including critical enzymes involved in biotransformation, metabolic pathway networks, genome-phenotype, and learning prediction. It highlights the significant roles and potential benefits of emerging cutting-edge technologies in advancing lignin valorization. Overall, synthetic biology-guided metabolic regulation has demonstrated its power in balancing the metabolic fluxes of ligninolytic strains, ensuring the continued vitality in future development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.