Evidence map›Paper›PMID 41268351›Full record

ArticleBioactive materials2025

Immunomodulatory copper-based polyphenol nanozyme for diabetic infectious wound healing via NIR amplified cuproptosis bacteriostat in synergy with ferroptosis inhibition anti-inflammation.

Huyang Gao, Juan Luo, Xixi Chen, Yaohui Huang, Mengxue Mo, Qianyu Luo, Yan Liu, Binbin Zou, Yanjun Lei, Zhengzhao Li and 11 more

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026
    Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Huyang GaoIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
Juan LuoDepartment of Endocrinology, Department of Hematology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 410005, China.
Xixi ChenIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
Yaohui HuangDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Mengxue MoDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Qianyu LuoLife Sciences Institute, Guangxi Medical University, Nanning, Guangxi, 530021, China.
Yan LiuDepartment of Colorectal and Anal Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530021, China.
Binbin ZouDepartment of Endocrinology, Department of Hematology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 410005, China.
Yanjun LeiDepartment of Endocrinology, Department of Hematology, Hunan Provincial People's Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, 410005, China.
Zhengzhao LiIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
Linhai HuangIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
Xiaolin HuangIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Peng LiangIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Meihua LinIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Jingju HuangIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Hongsheng LuIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Hualin HuangIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Huile GaoKey Laboratory of Drug-Targeting and Drug Delivery System of the Education Ministry, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan, 610041, China.
Jianfeng ZhangIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.
Junyu LuIntensive Care Unit, The Second Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, 530007, China.
Ming GaoIntensive Care Unit, Department of Orthopedics, Wuming Hospital of Guangxi Medical University, Nanning, Guangxi, 530199, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetic infectious wound is usually in the environment of high glucose levels and immune disorder. It always results in high reactive oxygen species (ROS) levels, serious immune dysfunction, and extreme susceptibility to infection, delaying wound healing. Herein, we prepared an immunomodulatory polyphenol metal organic framework nanozyme (CE) combined with near infrared (NIR) irradiation for diabetic infectious wound healing. This nanozyme was formed by the self-assembly of Cu ions and ellagic acid.

Indexed as

Diabetic infectious woundFerroptosis inhibition anti-inflammationImmunoregualtion activationMacrophage M2 polarizationNatural polyphenol nanozymeNIR amplified cuproptosis

Identifiers

PMID41268351
PMCPMC12628149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.