ArticleBioactive materials2025
Jahn-Teller distortion-engineered self-propelled nanorobots for mitochondrial targeting and bioenergetic disruption in tumor therapy.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Destroy and reconstruct: A microneedle platform for combined NIR-II photothermal therapy and asiaticoside-mediated tissue regeneration in cutaneous amyloidosis.Materials today. Bio · 2026Article
- A phthalocyanine‑derived covalent organic framework nanoplatform with boosted sonodynamic efficacy for apigenin co‑delivery and combined antitumor therapy.Mikrochimica acta · 2026Article
- Dynamic collaboration between mitochondria and organelles: mechanisms, functions, and disease implications.Apoptosis : an international journal on programmed cell death · 2026Review
- Nano-Immunotherapy Targeting TAMs: Precisely Regulating TAMs to Reverse Immunosuppressive TME.International journal of nanomedicine · 2026Review
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14 authors.
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Abstract
Mitochondrial metabolism plays a pivotal role in tumor progression, yet effective therapeutic targeting remains constrained by limited tissue penetration and lack of spatiotemporal control. Herein, we present Jahn-Teller distortion-engineered, self-propelled nanorobots (IDP@Z@AP) that integrate catalytic oxygen generation, mitochondria-targeted drug delivery, and real-time 3D NIR-II photoacoustic (PA) imaging for precision tumor therapy. The nanorobots are fabricated by co-encapsulating a NIR-II photothermal agent (IR1048) and a mitochondria-targeting chemotherapeutic (DOX-TPP) within a ZIF-8 framework, followed by in situ anchoring of ultrasmall AuPt bimetallic nanozymes. Pt-induced Jahn-Teller distortion modulates the electronic structure of AuPt, enhancing glucose oxidase- and catalase-like activities. Under NIR-II laser irradiation, photothermal-enhanced cascade catalysis drives autonomous motion and catalyzes intratumoral O
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