ArticleBioactive materials2025
Hydrogel scaffold encapsulating MSC-Exos and ZIF-8 promotes bone regeneration via coordinating osteogenesis and immunomodulation.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Metabolic targeting by a small extracellular vesicle-based cellulose-GelMA hydrogel restores neurovascular regeneration in diabetic nerve injury.Bioactive materials · 2027Article
- Attapulgite Nanocomposites for Cartilage and Osteochondral Repair: Material-Tissue Matching, Evidence-Graded Mechanisms and Translation.Nanomaterials (Basel, Switzerland) · 2026Review
- Hydrogel Implementing Drug Delivery in Cranial Bone Tissue Engineering.Journal of functional biomaterials · 2026Review
- An infection-responsive multifunctional hydrogel enables potent activity against methicillin-resistantMaterials today. Bio · 2026Article
- Smart and stimuli-responsive hydrogels for controlled exosome delivery in bone tissue engineering: from passive carriers to intelligent therapeutic platforms.Cell and tissue banking · 2026Review
- Injectable Porous Microspheres Loaded With Biomimetic Preconditioned Bone Marrow Mesenchymal Stem Cell-Derived Exosomes for Vascularized Bone Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- High-performance hydrogels in orthopedics: Structural design, performance tuning, and clinical potential.Materials today. Bio · 2026Review
- Modular assembly of nanocomposite hydrogel with NIR-responsive black phosphorus release and mild photothermal synergy for enhanced regenerative microenvironment and accelerated infectious bone repair.Journal of nanobiotechnology · 2026Article
- Preparation and characterization of zeolite imidazole framework-8@quercetin nanoparticle/sodium alginate/L-cysteine/calcium ion hydrogel films for fruit preservation.Food chemistry: X · 2026Article
- Orchestrating the immuno-chondrogenic microenvironment via a bio-inorganic hybrid microsphere system for tendon-to-bone healing.Materials today. Bio · 2026Article
- Exosome-loaded hydrogels for bone regeneration: a cell-free therapeutic strategy.Journal of biological engineering · 2026Review
- Engineering MSC-exosomes for diabetic bone regeneration: from mechanism to delivery.Stem cell research & therapy · 2026Review
- Smart integrated biomaterial systems for precision and optimized delivery of MSCs and their exosomes: Transforming wound healing and organ regeneration.Regenerative therapy · 2026Review
- ZIF-8-Based Nanomedicine for Bone Regeneration: A Critical Appraisal of Preclinical Osteoimmunomodulatory Evidence and Translational Readiness.International journal of nanomedicine · 2026Review
- Stem cell-derived extracellular vesicles -mediated bone regeneration: mechanisms, targeted delivery, and clinical perspectives in promoting angiogenesis.Frontiers in bioengineering and biotechnology · 2026Review
- Nanozymes for Bone Regeneration: Mechanistic Insights into Immune and Metabolic Microenvironment Modulation.International journal of nanomedicine · 2026Review
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The limited bone regeneration and suboptimal immune responses constitute the major challenges in repairing critical-sized bone defects. As an emerging therapeutic modality, mesenchymal stem cell-derived exosomes (MSC-Exos) exhibit promising application prospects in bone regeneration. In this study, the bone-functionalized MSC-Exos are loaded into GelMA hydrogel scaffolds modified with the bone immunomodulator Zeolitic Imidazolate Framework-8 (ZIF-8) for the repair of critical-sized bone defects. The prepared MSC-Exos/ZIF-8@GelMA composite hydrogel demonstrates excellent biocompatibility and favors the adhesion and proliferation of bone marrow mesenchymal stem cells (BMSCs). The sustained release of exosomes and zinc ions endows the composite hydrogel with synergistically enhanced bone regeneration, angiogenesis, and immunomodulation. Specifically, the microRNA-23a-3p within internalized MSC-Exos activates the AKT signaling pathway in BMSCs by targeting the PTEN node and up-regulates the expression of osteogenesis-related markers. Meanwhile, it is demonstrated for the first time that ZIF-8 inhibits the activation of the non-classical NF-κB pathway in RAW264.7 cells under simulated inflammatory conditions, thereby downregulating pro-inflammatory cytokine expression and inducing M2-type polarization. The rat cranial bone defect model demonstrates that the composite hydrogel significantly enhances new bone formation and angiogenesis
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