ArticleBioactive materials2025
Spontaneous dynamic modulation of ionic/immune microenvironment on polyetheretherketone for sequential anti-infection and osseointegration.
Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
- Immune regulative GelMA&ZnBioactive materials · 2026Article
- Near-Infrared Switch-Driven Macrophage Dynamically Reprogramming for Anti-Infection and Tissue Healing on Polyetheretherketone Implants.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
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Authors and funding
13 authors.
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Abstract
Initial implant-related infection and subsequent poor osseointegration are the main causes of implant placement failure. The extracellular microenvironment is an important mediator of behaviors of cell and bacteria; however, spontaneously dynamically regulating the microenvironment to match tissue integration processes remains a challenge. Here, we construct a multilayer film on polyetheretherketone (PEEK) surface with different inner and outer layers of magnesium oxide (MgO) degradation rates. This film can sequentially regulate surface ions and immune microenvironment to achieve sequential antibacteria and bone integration. In the early stage of bone implantation, the outer layer of MgO can rapidly degrade to produce a strong alkaline microenvironment and a large amount of magnesium (Mg) ions, disrupting the energy metabolism of adherent bacteria and inducing M1 polarization of macrophages to enhance their ability to engulf planktonic bacteria. In the later stage, the inner layer MgO can slowly release Mg ion for a long time, synergistically promoting the proliferation and differentiation of osteoblasts by directly stimulating osteoblasts and inducing M2 polarization of macrophages. The rat femoral implantation model confirms the good sequential immune-enhanced antibacteria and bone integration ability of the film
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