Evidence map›Paper›PMID 41268340›Full record

ArticleBioactive materials2025

Bioengineering an improved three-dimensional vascularized co-culture model for studying Neuron-Microglia interactions.

Yinhe Han, Lina Guo, Mingqi Wang, Zhen Cao, Xu Zheng, Xinyu Wang, Lingling Jin, Xiaoqing Wei, Xiuli Wang, Jie Zhao

Abstract read
In one paragraph

Article in Bioactive materials, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Engineering Silk Fibroin-Based Biomaterials for Neural Repair.Advanced materials (Deerfield Beach, Fla.) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yinhe HanCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Lina GuoCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Mingqi WangCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Zhen CaoCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Xu ZhengCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Xinyu WangCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Lingling JinNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian, 116044, China.
Xiaoqing WeiCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Xiuli WangCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.
Jie ZhaoCollege of Basic Medical Science, Dalian Medical University, Dalian, 116044, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interactions among neurons, microglia, and endothelial cells (ECs) -the principal components of the neurovascular unit (NVU)-are vital for maintaining central nervous system (CNS) homeostasis and are implicated in numerous neurological disorders. However, mechanistic insights into their crosstalk remain limited due to the lack of physiologically relevant

Indexed as

Human-induced neural stem cells (hiNSCs)Human vascular organoidsImmune-neurovascularMicrogliaSDF-1/CXCR4Vascularization

Identifiers

PMID41268340
PMCPMC12628055

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.