Evidence map›Paper›PMID 41268305›Full record

ArticleJournal of ginseng research2025

Korean red ginseng extract suppresses food allergy by remodeling the gut microbiota and restoring immune homeostasis in IL4ra

Suyoung Choi, Thi Thuy Duong Pham, Tae-Keun Jeong, Ju-Gyeong Kang, Sang-Woo Lee, Bu Yeon Heo, Jung-Hyun Park, Jeong Suk Koh, Myung-Won Lee, Dae-Sik Lim and 2 more

Abstract read
In one paragraph

Article in Journal of ginseng research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
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  4. Journal of ginseng research · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Suyoung ChoiDepartment of Infection Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Thi Thuy Duong PhamDepartment of Infection Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Tae-Keun JeongNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Ju-Gyeong KangNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Sang-Woo LeeDepartment of Infection Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Bu Yeon HeoDepartment of Infection Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Jung-Hyun ParkTranslational Immunology Institute, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Jeong Suk KohDepartment of Internal Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Myung-Won LeeDepartment of Internal Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Dae-Sik LimNational Creative Research Center for Cell Plasticity, KAIST Stem Cell Center, Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon, 34141, Republic of Korea.
Ik-Chan SongDepartment of Internal Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.
Jaeyul KwonDepartment of Infection Biology, College of Medicine, Chungnam National University, Daejeon, 35015, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Food allergy (FA) is a growing health concern with limited therapeutic options. While Korean Red Ginseng Extract (KRGE) exhibits immunomodulatory and microbiota-modulating properties, its specific effects and mechanisms in FA are not fully understood. Methods: We evaluated the anti-allergic efficacy of KRGE in IL4ra Results: Results showed KRGE significantly suppressed anaphylactic symptoms, including hypothermia and mortality, and reduced OVA-specific IgE and IL-33 levels. KRGE restored intestinal epithelial integrity and normalized Peyer's patch hypertrophy. Immunologically, it decreased IL-13-producing T follicular helper cells and rebalanced dendritic cell subsets, increasing tolerogenic CD103 Conclusion: KRGE mitigates FA in IL4ra

Indexed as

Akkermansia muciniphilaAnaphylaxisDendritic cellsFood allergyGut microbiotaImmune toleranceKorean red ginseng extract

Identifiers

PMID41268305
PMCPMC12629723

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.