ArticleAmerican journal of translational research2025
Impact of platelet-rich plasma intrauterine perfusion on endometrial receptivity and pregnancy outcomes in patients with recurrent implantation failure and thin endometrium.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The Value of Platelet-Rich Plasma Treatment in Reproductive Disorders: An Umbrella Review.American journal of reproductive immunology (New York, N.Y. : 1989) · 2026Pooled it
- Effect of zero-time exercise intervention on endometrial receptivity in women with thin endometrium a single-center randomized sham-controlled trial.Archives of gynecology and obstetrics · 2026Trial
- Platelet-Rich Plasma in Recurrent Pregnancy Loss: Toward a Precision Medicine Framework for Biologically Guided Patient Selection.Medical sciences (Basel, Switzerland) · 2026Review
- Endometrial Repair and Regenerative Medicine: From Broad-Spectrum Regeneration to Precision Intervention.Reproductive sciences (Thousand Oaks, Calif.) · 2026Review
- Impact of Intrauterine Infusion of Autologous Platelet-Rich Plasma on Assisted Reproductive Outcomes in Patients With Recurrent Implantation Failure: A Meta-Analysis of Randomized Controlled Trials.Reproductive medicine and biologyReview
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate the impact of autologous platelet-rich plasma (PRP) intrauterine perfusion on endometrial receptivity and pregnancy outcomes in patients with implantation failure.
methodsThis retrospective cohort study included patients who visited our hospital between January 2019 and January 2024, all suffering from recurrent implantation failures and diagnosed with thin endometrium. Participants were divided into two groups: conventional-treatment (n=116) and PRP-treatment (n=104). Serum levels of estradiol 2 (E2), follicle stimulating hormone (FSH), and luteinizing hormone (LH) were measured before and 14 days after treatment. Transvaginal Doppler ultrasound assessed uterine artery, arcuate artery, and spiral artery pulsatility index (PI) and resistance index (RI) at both timepoints. Endometrial thickness was measured before and 14 days post-treatment. Pregnancy outcomes, including implantation rate, clinical pregnancy rate, ongoing pregnancy rate, and live birth rate, were recorded.
resultsThe PRP-treatment group showed a significant increase in endometrial thickness (P=0.037). Uterine artery PI (P=0.004) and RI (P=0.015), arcuate artery PI (P=0.037) and RI (P=0.003), and spiral artery PI (P=0.002) significantly decreased in the PRP-treatment group compared to the conventional-treatment group. Hormonal measurements indicated higher E2 (P=0.001) and lower FSH (P=0.002) and LH (P=0.002) levels post-treatment in the PRP-treatment group. Pregnancy outcomes significantly favored the PRP-treatment group, with higher implantation rates (P=0.004), clinical pregnancy rates (P=0.044), ongoing pregnancy rates (P=0.031), and live birth rates (P=0.032).
conclusionPRP intrauterine perfusion significantly improves endometrial parameters, uterine hemodynamics, and pregnancy outcomes in patients with recurrent implantation failure and thin endometrium.
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