ArticleAmerican journal of translational research2025
Escin displays neuroprotective effects in mice with intracerebral hemorrhage through ameliorating intestinal injury.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Escin Attenuates Amyloid Beta 1-42-Induced Oxidative Stress, Apoptosis, and Neuroinflammation in Neuron-Like SH-SY5Y Cells.Journal of biochemical and molecular toxicology · 2026Article
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Authors and funding
7 authors.
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Abstract
objectiveTo investigate the relationship between secondary brain injury and intestinal injury in intracerebral hemorrhage (ICH) and whether escin can protect the function of the intestine and inhibit lipopolysaccharide (LPS) entry into the blood, thereby attenuating brain injury after ICH.
methodsMice were injected stereotactically with collagenase to establish a model of ICH. The Garcia test, forelimb placement test, brain water content, blood-brain barrier (BBB) permeability, intestinal injury, intestinal permeability, and serum LPS levels were evaluated. The ICH mice were treated with escin to investigate the effect of escin on intestinal injury and neurological function.
resultsThe severity of secondary brain injury was highly correlated with the degree of intestinal injury. After administering escin, intestinal injury was significantly alleviated, intestinal permeability was markedly reduced, and LPS blood levels were significantly decreased. Additionally, results from the Garcia and forelimb placement tests showed significant improvement. However, intraperitoneal injection of LPS, simulating the entry of LPS into the bloodstream due to intestinal injury, weakened the neuroprotective effects of escin without affecting its intestinal protective effects.
conclusionsThe ICH-induced brain injury caused intestinal barrier damage, resulting in LPS in the gut to enter blood circulation, which subsequently disrupted the BBB. Therefore, LPS plays an important role in ICH-induced secondary brain injury. Escin exerts its neuroprotective effect by attenuating gut injury following ICH.
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