ArticleAmerican journal of translational research2025
Clinical efficacy and safety analysis of minimally invasive tube placement, aspiration, liquefaction and drainage surgery for patients with cerebral hemorrhage.
Article in American journal of translational research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Advances in Stereotactic Hematoma Evacuation for Hypertensive Intracerebral Hemorrhage and the Value of Multimodal Monitoring.Cerebrovascular diseases (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
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Abstract
objectiveTo evaluate the clinical efficacy and safety of minimally invasive tube placement combined with aspiration, liquefaction, and drainage in patients with cerebral hemorrhage.
methodsA total of 99 patients with cerebral hemorrhage admitted to our hospital between February 2022 to February 2024 were enrolled. Among them, 47 patients received traditional craniotomy (control group), and 52 patients underwent minimally invasive tube placement, aspiration, liquefaction, and drainage in addition to conservative treatment (research group). Clinical efficacy, safety (incidence of venous thrombosis, gastrointestinal bleeding, urinary tract infection, and pulmonary infection), surgery-related indicators (operative duration, hematoma clearance rate on postoperative day 1, edema volume on postoperative day 7), neurological function (National Institutes of Health Stroke Scale (NIHSS)), activities of daily living (Barthel Index), 30-day mortality risk (Intracerebral Hemorrhage Score (ICH)), 90-day functional outcome (Functional Outcome in Patients with Primary Intracerebral Hemorrhage Score (FUNC)), serum inflammatory factors (tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), C reactive protein (CRP)), oxidative stress indicators (superoxide dismutase (SOD), malondialdehyde (MDA)), cerebrovascular function-related indices (calcitonin gene-related peptide (CGRP), endothelin (ET)), rebleeding incidence, and morbidity and mortality were compared between the two groups.
resultsThe research group demonstrated significantly higher total effectiveness rates (96.15% VS. 76.60%, P=0.048) and hematoma clearance rate on postoperative day 1 in the research group compared with the control group (P<0.001). The incidence of venous thrombosis, gastrointestinal bleeding, urinary tract infection, and pulmonary infection, as well as the overall complication rate were comparable between groups (P>0.05). The research group exhibited shorter operative duration and lower edema volume on postoperative day 7 (P<0.001). Post-treatment NIHSS score, ICH score, FUNC score, TNF-α, IL-6, CRP, MDA, and ET levels were significantly lower, whereas Barthel Index, SOD, and CGRP levels were significantly higher compared with both pre-treatment and control group values (all P<0.05). No significant differences were observed in rebleeding, morbidity, and mortality rates between groups (P>0.05).
conclusionMinimally invasive tube placement combined with aspiration, liquefaction and drainage demonstrates definite clinical efficacy and favorable safety in the treatment of cerebral hemorrhage.
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