ArticleFrontiers in endocrinology2025
Relationship between systemic immune-inflammation index and all-cause mortality in stages IIIB-IV epidermal growth factor receptor-mutated lung adenocarcinoma.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Inflammatory-Molecular Clusters as Predictors of Immunotherapy Response in Advanced Non-Small-Cell Lung Cancer.Journal of clinical medicine · 2026Article
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Abstract
Background: This study investigates the relationship between the systemic immune-inflammation index (SII) and all-cause mortality (ACM) risk in individuals with stages IIIB-IV epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma. Methods: The clinical data of 187 individuals with stages IIIB-IV EGFR-mutated lung adenocarcinoma from Anhui Chest Hospital, collected from June 2017 to December 2023, were retrospectively analyzed. SII was calculated as platelet count × neutrophil count/lymphocyte count. The receiver operating characteristic (ROC) curve was employed to determine the optimal threshold SII, and individuals were classified as low and high SII groups. ACM serves as the primary endpoint. Univariate and multivariate analyses were conducted using Cox proportional hazards models. The robustness of the findings was tested by subgroup and sensitivity analyses. Results: The ACM risk was notably elevated in the high SII group ( Conclusion: Elevated SII is an independent biomarker for predicting ACM in individuals with stages IIIB-IV EGFR-mutated lung adenocarcinoma, with a stronger predictive value in male and older populations.
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