ArticleFrontiers in endocrinology2025
Association of TNF-α polymorphisms rs1800629 (-308G>A) and rs361525 (-238G>A) with type 2 diabetes mellitus in the Punjabi population of Pakistan.
Article in Frontiers in endocrinology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed.
- Molecular Mechanisms Associated with Metabolic Dysfunction: Contributions of Nutritional Genomics.Metabolites · 2026Review
- Article
- Cytokine Gene Polymorphisms Modulate Isohemagglutinin Titers and Classes: Another Aspect Towards the Link Between ABO Groups and Human Pathologies?International journal of molecular sciences · 2026Article
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7 authors.
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Abstract
Background: The Methods: A case-control study was conducted including 100 clinically diagnosed T2DM patients and 100 healthy controls. Genotyping of Results: The A alleles of rs1800629 and rs361525 were significantly more frequent in T2DM cases compared to controls (3.68% vs. 0.54%, OR = 6.779, p = 0.037 for rs1800629; 5.26% vs. 0.53%, OR = 9.684, p = 0.006 for rs361525). Fasting blood sugar level (FBS) of 150 ± 45 mg/dL was recorded in diabetic subjects. Multivariate and forest plot analyses supported the association of both variants with increased T2DM risk. Control group genotypes conformed to Hardy-Weinberg equilibrium, validating population stability. Conclusion: In this Punjabi cohort from Pakistan, the A alleles of TNF-α promoter polymorphisms rs1800629 and rs361525 were significantly more frequent in T2DM cases, indicating that these variants increase susceptibility to T2DM in this population.
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