ArticleDiscover imaging2025
Repeatability and reproducibility of quantitative ultrasound cervical measurements in women at risk for preterm birth.
Article in Discover imaging, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Characterization of Cervical Remodeling During Pregnancy and the Postpartum Period: A Case Series Analysis.The American journal of case reports · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Transvaginal Quantitative Ultrasound (QUS) has the potential to enhance preterm birth risk monitoring during pregnancy but evidence on the reliability of commonly used QUS parameters in vivo is lacking. This study assesses intra-sonographer repeatability and inter-sonographer reproducibility of six different QUS measurements of the human cervix during pregnancy: Attenuation Coefficient (AC), Lizzi Feleppa (LF) Intercept, Midband and Slope, and Envelope Kappa and Mu. Methods: This prospective study was approved by the institutional review board at the University of Illinois, Chicago. Informed consent was obtained from all participants, who were selected from pregnant women enrolled in the single-center study, "QUS Technology for Identifying At-Risk Women for Spontaneous Preterm Birth." They received a standard clinical transvaginal ultrasound scan followed by two research scans at 20 ± 2 and 24 ± 2 weeks of gestation. During one or both research scans, they underwent two independent examinations (same-sonographer or cross-sonographer). QUS measurements were computed from ultrasound radiofrequency (RF) data. Variation attributable to transducers, phantoms, and sonographers was evaluated by linear mixed model analysis. QUS parameters were averaged over four acquisitions from each examination. Repeatability and reproducibility were evaluated using the coefficient of variation (CoV), intraclass correlation coefficient (ICC), and Bland-Altman analysis. Results: Eighty-one participants (mean age, 27.12 years ± 5.81) were recruited for a total of 82 examination pairs, yielding 36 intra-sonographer and 46 inter-sonographer pairs of examinations. Transducer and reference phantom variances were not statistically significant ( Conclusion: Averaged in vivo transvaginal QUS measurements of AC and LF Midband have potential for development as noninvasive clinical measurements with moderate reproducibility for auxiliary monitoring of the progress of pregnancy. The other QUS parameters evaluated in this study require further refinement before they can be recommended for clinical use. Supplementary Information: The online version contains supplementary material available at 10.1007/s44352-025-00020-3.
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