ReviewFrontiers in oncology2025
The role of lactylation in breast cancer development: mechanisms, clinical translation and new strategies for treatment.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Lactate metabolism and protein lactylation in inflammatory and tumor microenvironments.Molecular biomedicine · 2026Review
- Lysine lactylation-mediated post-translational modification: Molecular mechanisms and therapeutic target exploration in tumour drug resistance.Clinical and translational medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Worldwide, breast cancer (BC) is a common and deadly illness that poses a serious risk to women's health. Its development is intimately associated with tumor microenvironment (TME) alteration and metabolic problems. Lactic acid, a principal byproduct of glycolysis, not only facilitates the acidity of the TME but also interferes with cellular circadian rhythms. Moreover, it exerts multifaceted regulatory effects on breast cancer growth by facilitating a new post-translational modification(PTM)ficatio lactylation (Kla). By accelerating metabolic reprogramming, encouraging immunological microenvironment dysregulation, and intensifying tumor growth, metastasis, and chemoresistance, Kla has been shown in studies to contribute to the advancement of BC and poor prognosis. Lactate production and transport, especially targeting lactate dehydrogenase (LDH) and monocarboxylate transporter protein (MCT), show promise in BC treatment. Both tumor-suppressive and immunotherapy-enhancing effects are exhibited by inhibitors that target LDH and MCTs, and they may work in concert with immunotherapy. The function of Kla in BC, its underlying processes, and the possibility of treating the condition by specifically targeting Kla are all examined in this review. Additionally, it suggests the creation of precision-targeted treatments, providing fresh viewpoints on metabolic treatments and combination treatments for BC.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.